Zifday
Generic Name
Ziphenhydramine
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zifday 50 mg capsule | ৳ 3.50 | ৳ 35.00 |
Description
Overview of the medicine
Zifday 50 mg Capsule is an anxiolytic medication used to treat generalized anxiety disorder and panic attacks. It works by enhancing the reuptake of serotonin in the brain, helping to stabilize mood and reduce feelings of anxiety.
Uses & Indications
Dosage
Adults
Initial dose 50 mg once daily, may be increased to 100 mg daily based on response. Taken with or without food.
Elderly
Initial dose 25 mg once daily, carefully titrated based on clinical response and tolerability.
Renal_impairment
No dose adjustment needed for mild to moderate impairment. For severe impairment, start with 25 mg daily.
How to Take
Take the capsule orally with a glass of water, once daily, with or without food. Do not chew or crush the capsule.
Mechanism of Action
Zifday (Ziphenhydramine) selectively enhances the reuptake of serotonin (5-HT) in the central nervous system, leading to increased extracellular serotonin levels and improved synaptic neurotransmission. This modulation of serotonergic activity helps to alleviate anxiety symptoms.
Pharmacokinetics
Onset
Anxiolytic effects begin within 1-2 hours, full effect in 2-4 weeks.
Excretion
Mainly excreted via urine as metabolites, with a small portion excreted unchanged.
Half life
Approximately 12-18 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via CYP450 enzymes (e.g., CYP2D6, CYP3A4).
Side Effects
Contraindications
- •Hypersensitivity to Ziphenhydramine or any excipients
- •Concomitant use with MAOIs
- •Severe hepatic impairment
Drug Interactions
MAOIs
Concurrent use is contraindicated due to risk of serotonin syndrome.
SSRIs/SNRIs
Increased risk of serotonin syndrome; monitor closely.
CNS Depressants
Additive sedative effects; use with caution.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe drowsiness, confusion, rapid heartbeat, seizures, and coma. Treatment is supportive, focusing on maintaining vital functions and symptomatic management. Gastric lavage or activated charcoal may be considered in acute overdose.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by national regulatory authority
Patent Status
Under patent
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in