Ziflu
Generic Name
Oseltamivir Phosphate
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ziflu 10 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Ziflu 10 mg Syrup is an antiviral medication used to treat and prevent influenza (flu) caused by influenza A and B viruses. It works by stopping the flu virus from spreading inside the body.
Uses & Indications
Dosage
Adults
Treatment: 75 mg twice daily for 5 days. Prophylaxis: 75 mg once daily for at least 7-10 days.
Elderly
No dosage adjustment needed for elderly patients unless renal impairment is present. Follow adult dosage.
Renal_impairment
Dosage adjustment is required for patients with creatinine clearance ≤30 mL/min. Consult a physician for specific recommendations.
How to Take
Ziflu syrup should be taken orally, with or without food. Taking it with food may improve tolerability and reduce gastrointestinal side effects. An appropriate measuring device should be used for accurate dosing.
Mechanism of Action
Oseltamivir is a selective inhibitor of influenza virus neuraminidase, an enzyme essential for viral replication and the release of progeny virus from infected cells. By inhibiting neuraminidase, Oseltamivir prevents the virus from budding from the host cell and spreading to other cells.
Pharmacokinetics
Onset
Symptom improvement is typically observed within 1-2 days of initiation of treatment.
Excretion
The active metabolite, oseltamivir carboxylate, is primarily excreted renally via glomerular filtration and tubular secretion.
Half life
The plasma elimination half-life of oseltamivir carboxylate is 6 to 10 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract and extensively converted to the active metabolite, oseltamivir carboxylate. Bioavailability of oseltamivir carboxylate is approximately 75%.
Metabolism
Primarily metabolized by hepatic esterases to the active metabolite, oseltamivir carboxylate. No involvement of cytochrome P450 isoenzymes.
Side Effects
Contraindications
- Known hypersensitivity to Oseltamivir Phosphate or any component of the formulation.
Drug Interactions
Probenecid
Coadministration with probenecid results in an approximate 2-fold increase in exposure to oseltamivir carboxylate. Dose adjustment is generally not required.
Live Attenuated Influenza Vaccine
Oseltamivir may inhibit the replication of live attenuated influenza vaccine. Avoid use of live attenuated influenza vaccine within 2 days before and 2 weeks after Ziflu administration.
Storage
Store unopened Ziflu syrup powder at room temperature (20°C-25°C). Store reconstituted suspension under refrigeration (2°C-8°C); do not freeze. Discard any unused portion after 10-17 days.
Overdose
Limited information is available regarding overdose. Symptoms of overdose are expected to be similar to known side effects. Management should be supportive and directed at the clinical symptoms.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Oseltamivir is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to Oseltamivir Phosphate or any component of the formulation.
Drug Interactions
Probenecid
Coadministration with probenecid results in an approximate 2-fold increase in exposure to oseltamivir carboxylate. Dose adjustment is generally not required.
Live Attenuated Influenza Vaccine
Oseltamivir may inhibit the replication of live attenuated influenza vaccine. Avoid use of live attenuated influenza vaccine within 2 days before and 2 weeks after Ziflu administration.
Storage
Store unopened Ziflu syrup powder at room temperature (20°C-25°C). Store reconstituted suspension under refrigeration (2°C-8°C); do not freeze. Discard any unused portion after 10-17 days.
Overdose
Limited information is available regarding overdose. Symptoms of overdose are expected to be similar to known side effects. Management should be supportive and directed at the clinical symptoms.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Oseltamivir is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened: 2-3 years (refer to specific product labeling). Reconstituted suspension: stable for 10-17 days when refrigerated (2°C-8°C).
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic versions available
WHO Essential Medicine
YesClinical Trials
Oseltamivir has undergone extensive clinical trials to establish its efficacy and safety in the treatment and prophylaxis of influenza in various age groups.
Lab Monitoring
- Routine laboratory monitoring is generally not required for patients taking Oseltamivir.
Doctor Notes
- Emphasize the importance of early initiation of treatment (within 48 hours of symptom onset) for optimal efficacy.
- Counsel patients on proper administration techniques, especially for pediatric dosing using the provided device.
- Monitor for neuropsychiatric events, particularly in children and adolescents, and advise caregivers to seek immediate medical attention if such events occur.
Patient Guidelines
- Start treatment as soon as flu symptoms appear, ideally within 48 hours.
- Complete the full course of medication, even if symptoms improve, to ensure full recovery and prevent recurrence.
- Use the provided measuring device for accurate dosing, especially for children.
Missed Dose Advice
If a dose is missed, take it as soon as possible if it is within 2 hours of the next scheduled dose. If not, skip the missed dose and return to your regular dosing schedule. Do not double the dose.
Driving Precautions
Dizziness and headaches are potential side effects. Patients should be cautious when driving or operating machinery until they know how Ziflu affects them.
Lifestyle Advice
- Get plenty of rest and drink adequate fluids.
- Practice good hand hygiene to prevent the spread of infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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