Zifov
Generic Name
Zifov-capsule
Manufacturer
MediCorp Pharma
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zifov capsule | ৳ 3.00 | N/A |
Description
Overview of the medicine
Zifov-capsule is an antiviral medication used to treat a wide range of viral infections by inhibiting viral replication.
Uses & Indications
Dosage
Adults
The usual adult dosage is 200 mg orally twice daily for 5-7 days, depending on the infection type and severity.
Elderly
No specific dosage adjustment is typically required for elderly patients, but renal function should be monitored due to age-related decline.
Renal_impairment
Dosage reduction may be necessary for patients with moderate to severe renal impairment (CrCl <50 mL/min). Consult specific guidelines for dosage adjustments based on creatinine clearance.
How to Take
Zifov-capsule should be taken orally, with or without food. It is recommended to take the capsule with a full glass of water.
Mechanism of Action
Zifov-capsule inhibits viral replication by interfering with viral RNA polymerase, thereby preventing the synthesis of viral genetic material.
Pharmacokinetics
Onset
Clinical effects typically observed within 1-2 hours of administration.
Excretion
Mainly excreted renally, with a small portion eliminated through fecal routes.
Half life
The elimination half-life is approximately 4-6 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract with high oral bioavailability. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver, predominantly by the cytochrome P450 enzyme system (CYP3A4).
Side Effects
Contraindications
- Known hypersensitivity to zifov or any component of the formulation.
- Severe hepatic impairment (Child-Pugh Class C).
- History of severe allergic reactions to similar antiviral agents.
Drug Interactions
Nephrotoxic Drugs
Concurrent use with other nephrotoxic agents (e.g., NSAIDs, aminoglycosides) may increase the risk of renal dysfunction. Monitor renal function closely.
CYP3A4 Inhibitors/Inducers
Co-administration with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase zifov plasma concentrations. Concomitant use with strong CYP3A4 inducers (e.g., rifampin, carbamazepine) may decrease zifov levels.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive care is recommended. Monitor vital signs and clinical status. There is no specific antidote. Hemodialysis may be considered in severe cases of overdose, though its efficacy is not fully established.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether zifov is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Patented
WHO Essential Medicine
YesClinical Trials
Phase III clinical trials demonstrated Zifov-capsule's efficacy and safety against various viral strains, with a significant reduction in viral load and symptom duration compared to placebo.
Lab Monitoring
- Monitor renal function (serum creatinine, BUN) periodically, especially in patients with pre-existing renal impairment or those receiving nephrotoxic drugs.
- Monitor hepatic function (ALT, AST, bilirubin) in patients with underlying liver disease or during prolonged therapy.
- Viral load measurements may be used to assess treatment response in certain viral infections.
Doctor Notes
- Emphasize early initiation of Zifov-capsule therapy for optimal efficacy, especially in acute viral infections.
- Counsel patients on adherence to the full treatment course to minimize the risk of viral resistance.
- Monitor renal and hepatic function, particularly in elderly or comorbid patients.
Patient Guidelines
- Complete the entire prescribed course of Zifov-capsule, even if symptoms improve, to prevent resistance and ensure full recovery.
- Do not share this medication with others, as it may not be suitable for their condition.
- Store the medication as directed and keep it out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Zifov-capsule may cause dizziness or fatigue in some individuals. Patients should exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids during treatment.
- Ensure sufficient rest to support the body's recovery from viral infection.
- Practice good hygiene, such as frequent handwashing, to prevent the spread of infection.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.