Zilic-TR
Generic Name
Itopride Hydrochloride (Sustained Release)
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zilic tr 150 mg capsule | ৳ 3.00 | N/A |
Description
Overview of the medicine
Zilic-TR 150 mg Capsule contains Itopride Hydrochloride as a sustained-release formulation. It is used to treat gastrointestinal symptoms associated with functional dyspepsia and other motility disorders.
Uses & Indications
Dosage
Adults
One 150 mg capsule once daily. Should be taken before meals.
Elderly
No specific dose adjustment is usually required, but caution is advised due to potential age-related physiological decline.
Renal_impairment
Use with caution in patients with renal impairment. Dose reduction may be considered based on clinical assessment.
How to Take
Take orally, preferably before meals, with a glass of water. Do not chew or crush the capsule.
Mechanism of Action
Itopride enhances gastric motility by acting as a dopamine D2 receptor antagonist and an acetylcholinesterase inhibitor. This dual mechanism increases acetylcholine concentration, promoting gastrointestinal prokinetic effects and accelerating gastric emptying.
Pharmacokinetics
Onset
Onset of action typically within 30-60 minutes for immediate release; sustained release provides a prolonged effect.
Excretion
Mainly excreted via urine, with some fecal excretion.
Half life
Approximately 6 hours for Itopride; TR formulation extends effective duration.
Absorption
Rapidly and well absorbed from the GI tract. Bioavailability is approximately 60% after oral administration.
Metabolism
Extensively metabolized in the liver, primarily by flavin-containing monooxygenase (FMO3).
Side Effects
Contraindications
- Known hypersensitivity to Itopride or any component of the formulation.
- Patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation.
- Patients with prolactinoma due to its dopamine D2 antagonist activity.
Drug Interactions
Dopamine agonists
Itopride may counteract the effects of dopamine agonists (e.g., bromocriptine, cabergoline) due to its D2 antagonist activity.
Anticholinergic drugs
Anticholinergic drugs (e.g., atropine, dicyclomine) may decrease the prokinetic effect of Itopride. Avoid concomitant use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and symptomatic supportive treatment are recommended. Monitor for extrapyramidal symptoms.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Itopride is excreted into breast milk; breastfeeding is not recommended.
Side Effects
Contraindications
- Known hypersensitivity to Itopride or any component of the formulation.
- Patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation.
- Patients with prolactinoma due to its dopamine D2 antagonist activity.
Drug Interactions
Dopamine agonists
Itopride may counteract the effects of dopamine agonists (e.g., bromocriptine, cabergoline) due to its D2 antagonist activity.
Anticholinergic drugs
Anticholinergic drugs (e.g., atropine, dicyclomine) may decrease the prokinetic effect of Itopride. Avoid concomitant use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and symptomatic supportive treatment are recommended. Monitor for extrapyramidal symptoms.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Itopride is excreted into breast milk; breastfeeding is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by relevant national regulatory bodies (e.g., DGDA in Bangladesh)
Patent Status
Generic available, original patent expired
Clinical Trials
Extensive clinical trials have established the efficacy and safety of Itopride in managing functional dyspepsia and other GI motility disorders.
Lab Monitoring
- Monitor complete blood count periodically, especially with long-term use.
- Monitor liver function tests periodically.
- Monitor prolactin levels if symptoms of hyperprolactinemia occur.
Doctor Notes
- Consider Itopride for patients with non-ulcer dyspepsia predominantly characterized by postprandial distress syndrome.
- Educate patients on potential hyperprolactinemia symptoms.
- Review concomitant medications for potential interactions, especially anticholinergics.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Report any unusual side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness. Patients should be cautioned about operating machinery or driving until they know how the medication affects them.
Lifestyle Advice
- Avoid fatty, spicy, and acidic foods that can worsen dyspepsia symptoms.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
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