Adults

For zinc deficiency: Consult physician. Typically 20-40 mg elemental zinc daily in divided doses. This 10mg syrup strength is not commonly used for adults.

Elderly

No specific dose adjustment is generally required, but caution is advised in individuals with pre-existing renal impairment.

Children

Acute diarrhea (6 months to 5 years): 20 mg elemental zinc (10 ml of 10 mg/5ml syrup) once daily for 10-14 days. Acute diarrhea (under 6 months): 10 mg elemental zinc (5 ml of 10 mg/5ml syrup) once daily for 10-14 days. For zinc deficiency: Consult physician. Dosage varies by age and severity.

Renal_impairment

Use with caution. Dosage adjustment may be required in severe renal impairment. Consult physician.

Onset

Therapeutic effects, especially in diarrhea, may be observed within a few days of starting treatment.

Excretion

Primarily via feces (about 90%) and to a lesser extent via urine and sweat.

Half life

Not clearly defined for elemental zinc, as it's widely distributed and utilized. The biological half-life can range from 100 to 300 days depending on various factors.

Absorption

Approximately 20-30% of ingested zinc is absorbed from the small intestine, primarily duodenum and jejunum. Absorption is influenced by dietary factors and other mineral intake.

Metabolism

Zinc is not metabolized in the traditional sense; it is incorporated into various proteins and enzymes throughout the body.

Penicillamine

Zinc may decrease the absorption of penicillamine.

Iron supplements

High doses of iron can interfere with zinc absorption. Separate administration times.

Calcium & Phytates

High intake of calcium or phytates (found in whole grains, legumes) can inhibit zinc absorption.

Tetracyclines & Quinolones

Zinc can reduce the absorption of tetracyclines and quinolone antibiotics. Administer zinc at least 2 hours before or 4-6 hours after these antibiotics.