Zinca
Generic Name
Zinc Sulfate (Elemental Zinc 10 mg/5 ml)
Manufacturer
Various Manufacturers
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zinca 10 mg syrup | ৳ 35.00 | N/A |
Description
Overview of the medicine
Zinca 10 mg syrup is an oral preparation of Zinc Sulfate, used to prevent and treat zinc deficiency, especially in children, and as an adjunct therapy in acute diarrhea.
Uses & Indications
Dosage
Adults
For zinc deficiency: Consult physician. Typically 20-40 mg elemental zinc daily in divided doses. This 10mg syrup strength is not commonly used for adults.
Elderly
No specific dose adjustment is generally required, but caution is advised in individuals with pre-existing renal impairment.
Children
Acute diarrhea (6 months to 5 years): 20 mg elemental zinc (10 ml of 10 mg/5ml syrup) once daily for 10-14 days. Acute diarrhea (under 6 months): 10 mg elemental zinc (5 ml of 10 mg/5ml syrup) once daily for 10-14 days. For zinc deficiency: Consult physician. Dosage varies by age and severity.
Renal_impairment
Use with caution. Dosage adjustment may be required in severe renal impairment. Consult physician.
How to Take
Oral administration. Can be taken with or without food. To reduce gastric irritation, it may be taken after meals. Use a measuring spoon/cup for accurate dosing.
Mechanism of Action
Zinc is an essential trace element vital for numerous biological processes including immune function, wound healing, DNA synthesis, and enzymatic reactions. It plays a crucial role in maintaining cell membrane integrity and has antioxidant properties. In diarrhea, it helps in regeneration of gut mucosa, enhances water and electrolyte absorption, and boosts immune response.
Pharmacokinetics
Onset
Therapeutic effects, especially in diarrhea, may be observed within a few days of starting treatment.
Excretion
Primarily via feces (about 90%) and to a lesser extent via urine and sweat.
Half life
Not clearly defined for elemental zinc, as it's widely distributed and utilized. The biological half-life can range from 100 to 300 days depending on various factors.
Absorption
Approximately 20-30% of ingested zinc is absorbed from the small intestine, primarily duodenum and jejunum. Absorption is influenced by dietary factors and other mineral intake.
Metabolism
Zinc is not metabolized in the traditional sense; it is incorporated into various proteins and enzymes throughout the body.
Side Effects
Contraindications
- Hypersensitivity to zinc sulfate or any component of the formulation
Drug Interactions
Penicillamine
Zinc may decrease the absorption of penicillamine.
Iron supplements
High doses of iron can interfere with zinc absorption. Separate administration times.
Calcium & Phytates
High intake of calcium or phytates (found in whole grains, legumes) can inhibit zinc absorption.
Tetracyclines & Quinolones
Zinc can reduce the absorption of tetracyclines and quinolone antibiotics. Administer zinc at least 2 hours before or 4-6 hours after these antibiotics.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, diarrhea, and irritation of the mouth and throat. Chronic overdose can lead to copper deficiency and anemia. Management: Symptomatic and supportive care. Gastric lavage may be considered if recent and severe. Chelation therapy (e.g., EDTA) may be needed in severe cases but is rarely necessary.
Pregnancy & Lactation
Pregnancy: Zinc is essential during pregnancy, but excessive doses should be avoided. Use as directed by a physician. Lactation: Zinc is excreted in breast milk. Generally considered safe at recommended doses, but consult a physician.
Side Effects
Contraindications
- Hypersensitivity to zinc sulfate or any component of the formulation
Drug Interactions
Penicillamine
Zinc may decrease the absorption of penicillamine.
Iron supplements
High doses of iron can interfere with zinc absorption. Separate administration times.
Calcium & Phytates
High intake of calcium or phytates (found in whole grains, legumes) can inhibit zinc absorption.
Tetracyclines & Quinolones
Zinc can reduce the absorption of tetracyclines and quinolone antibiotics. Administer zinc at least 2 hours before or 4-6 hours after these antibiotics.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, diarrhea, and irritation of the mouth and throat. Chronic overdose can lead to copper deficiency and anemia. Management: Symptomatic and supportive care. Gastric lavage may be considered if recent and severe. Chelation therapy (e.g., EDTA) may be needed in severe cases but is rarely necessary.
Pregnancy & Lactation
Pregnancy: Zinc is essential during pregnancy, but excessive doses should be avoided. Use as directed by a physician. Lactation: Zinc is excreted in breast milk. Generally considered safe at recommended doses, but consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date, or as indicated on the packaging.
Availability
Pharmacies, drugstores, hospitals
Approval Status
Approved by DGDA in Bangladesh
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support the efficacy of zinc supplementation in reducing the duration and severity of diarrhea, particularly in children in developing countries.
Lab Monitoring
- Serum zinc levels (if deficiency is severe or chronic)
- Copper levels (if high dose zinc therapy is prolonged to monitor for deficiency)
Doctor Notes
- Emphasize the importance of completing the full 10-14 day course for diarrhea.
- Advise parents on proper measurement and administration to children.
- Monitor for signs of copper deficiency in prolonged high-dose therapy.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Zinca 10 mg syrup is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in zinc (e.g., meat, nuts, legumes).
- Ensure adequate hydration, especially during diarrhea.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.