Ziron-F
Generic Name
Ferrous Fumarate 150 mg + Folic Acid 0.5 mg
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ziron f 150 mg capsule | ৳ 3.00 | N/A |
Description
Overview of the medicine
Ziron-F 150 mg capsule is a combination of Ferrous Fumarate and Folic Acid, primarily used to treat and prevent iron deficiency anemia and megaloblastic anemia, especially during pregnancy and lactation.
Uses & Indications
Dosage
Adults
Typically, 1 capsule daily, or as directed by the physician.
Elderly
Same as adult dosage, but caution with comorbidities.
Renal_impairment
No specific dosage adjustment usually required, but use with caution in severe renal impairment.
How to Take
Administer orally, preferably with or immediately after a meal to reduce gastrointestinal irritation. Do not chew or crush the capsule. May be taken with water.
Mechanism of Action
Ferrous Fumarate provides elemental iron, a crucial component of hemoglobin, myoglobin, and various enzymes. Folic acid is a B vitamin necessary for DNA synthesis, cell division, and erythropoiesis (red blood cell formation).
Pharmacokinetics
Onset
Gradual, correction of anemia seen within weeks.
Excretion
Iron primarily via feces (unabsorbed); Folic acid primarily via urine.
Half life
Iron not excreted via typical half-life; Folic acid approx. 3-10 hours.
Absorption
Iron absorbed primarily in the duodenum and upper jejunum; Folic acid absorbed primarily in the small intestine.
Metabolism
Iron incorporated into hemoglobin; Folic acid metabolized in the liver to active forms.
Side Effects
Contraindications
- Known hypersensitivity to Ferrous Fumarate, Folic Acid, or any excipients
- Hemochromatosis or other iron overload syndromes
- Repeated blood transfusions
- Pernicious anemia (without vitamin B12 supplementation)
Drug Interactions
Vitamin C
Enhances iron absorption.
Levothyroxine
Iron may reduce absorption of levothyroxine. Separate administration by at least 4 hours.
Tetracyclines and Quinolones
Iron can reduce the absorption of these antibiotics. Administer iron at least 2 hours before or 4-6 hours after these antibiotics.
Antacids (e.g., calcium carbonate, aluminum hydroxide)
May reduce iron absorption. Take iron 2 hours before or 4 hours after antacids.
Storage
Store in a cool, dry place, below 30°C, protected from light and moisture.
Overdose
Symptoms of iron overdose may include severe gastrointestinal irritation, nausea, vomiting, abdominal pain, diarrhea, pallor, cyanosis, and drowsiness. In severe cases, circulatory collapse, coma, and death may occur. Folic acid overdose is generally non-toxic. Seek immediate medical attention in case of suspected overdose.
Pregnancy & Lactation
Ziron-F is often recommended during pregnancy and lactation for the prevention and treatment of iron and folic acid deficiency, as these periods increase nutritional demands. Consult a doctor before use.
Side Effects
Contraindications
- Known hypersensitivity to Ferrous Fumarate, Folic Acid, or any excipients
- Hemochromatosis or other iron overload syndromes
- Repeated blood transfusions
- Pernicious anemia (without vitamin B12 supplementation)
Drug Interactions
Vitamin C
Enhances iron absorption.
Levothyroxine
Iron may reduce absorption of levothyroxine. Separate administration by at least 4 hours.
Tetracyclines and Quinolones
Iron can reduce the absorption of these antibiotics. Administer iron at least 2 hours before or 4-6 hours after these antibiotics.
Antacids (e.g., calcium carbonate, aluminum hydroxide)
May reduce iron absorption. Take iron 2 hours before or 4 hours after antacids.
Storage
Store in a cool, dry place, below 30°C, protected from light and moisture.
Overdose
Symptoms of iron overdose may include severe gastrointestinal irritation, nausea, vomiting, abdominal pain, diarrhea, pallor, cyanosis, and drowsiness. In severe cases, circulatory collapse, coma, and death may occur. Folic acid overdose is generally non-toxic. Seek immediate medical attention in case of suspected overdose.
Pregnancy & Lactation
Ziron-F is often recommended during pregnancy and lactation for the prevention and treatment of iron and folic acid deficiency, as these periods increase nutritional demands. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of iron and folic acid supplementation for anemia management.
Lab Monitoring
- Hemoglobin and hematocrit levels
- Serum ferritin (to assess iron stores)
- Red blood cell indices
Doctor Notes
- Confirm iron deficiency anemia diagnosis before prescribing.
- Educate patients on proper administration and potential side effects.
- Advise patients on diet to enhance iron absorption and manage GI side effects.
Patient Guidelines
- Take Ziron-F exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Store the medicine safely and keep it out of reach of children, as iron overdose can be fatal in young children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Ziron-F is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in iron (e.g., red meat, leafy greens) and Vitamin C.
- Stay well-hydrated to help manage potential constipation.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.