Zismo
Generic Name
Azithromycin
Manufacturer
General Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zismo 10 mg syrup | ৳ 35.00 | N/A |
Description
Overview of the medicine
Zismo 10 mg Syrup is an antibiotic medication containing Azithromycin. While Azithromycin is commonly found in higher concentrations (e.g., 100 mg/5 mL or 200 mg/5 mL), this specific formulation provides Azithromycin at a concentration of 10 mg per 5 mL. It is used to treat a variety of bacterial infections in the respiratory tract, skin, soft tissue, and ears.
Uses & Indications
Dosage
Adults
Not typically prescribed as 10 mg/5 mL syrup for adults. Adult dosage for Azithromycin is usually 250 mg or 500 mg.
Elderly
No specific dosage adjustment is required for elderly patients based on age alone; however, caution is advised in those with severe renal or hepatic impairment.
Children
For Zismo 10 mg/5 mL Syrup: The typical pediatric dosage for Azithromycin is 10 mg/kg orally once daily for 3 days, or 10 mg/kg on day 1 followed by 5 mg/kg once daily on days 2-5. For a child weighing 10 kg, this means 50 mL (100 mg) on Day 1, then 25 mL (50 mg) daily for Days 2-5 for the 5-day regimen. Always consult a physician for precise dosage.
Renal_impairment
No dosage adjustment is necessary for mild to moderate renal impairment. Use with caution in severe renal impairment (CrCl < 10 mL/min).
How to Take
Zismo syrup should be taken orally, with or without food. Taking it on an empty stomach may improve absorption, but taking it with food can help reduce gastrointestinal upset. Use the provided measuring device for accurate dosing.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby preventing the translocation of peptides. This action is primarily bacteriostatic, but can be bactericidal at high concentrations against certain organisms.
Pharmacokinetics
Onset
Onset of action typically within 2-3 hours.
Excretion
Primarily excreted unchanged in bile; a small amount is excreted in urine.
Half life
Terminal elimination half-life is long, ranging from 2 to 4 days.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37% due to significant first-pass metabolism.
Metabolism
Primarily metabolized in the liver, but extensive metabolism is not required for its activity.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Antacids
Concurrent administration with antacids containing aluminum or magnesium may reduce the peak serum concentrations of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Warfarin
Increased anticoagulant effects. Monitor INR/PT carefully.
Nelfinavir
Increased azithromycin serum concentrations. No dosage adjustment needed, but monitor for side effects.
Cyclosporine
Increased cyclosporine levels may occur. Monitor cyclosporine levels and adjust dosage if necessary.
QT Prolonging Drugs
Concurrent use with other drugs known to prolong the QT interval (e.g., antiarrhythmics, antipsychotics) may increase the risk of cardiac arrhythmias. Avoid concomitant use if possible.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children. Reconstituted suspension stable for 5-10 days at room temperature, depending on formulation.
Overdose
Symptoms of overdose typically include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures, gastric lavage, and monitoring of vital signs.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, use in pregnancy only if clearly needed. Azithromycin is excreted in human milk; use with caution during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Antacids
Concurrent administration with antacids containing aluminum or magnesium may reduce the peak serum concentrations of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Warfarin
Increased anticoagulant effects. Monitor INR/PT carefully.
Nelfinavir
Increased azithromycin serum concentrations. No dosage adjustment needed, but monitor for side effects.
Cyclosporine
Increased cyclosporine levels may occur. Monitor cyclosporine levels and adjust dosage if necessary.
QT Prolonging Drugs
Concurrent use with other drugs known to prolong the QT interval (e.g., antiarrhythmics, antipsychotics) may increase the risk of cardiac arrhythmias. Avoid concomitant use if possible.
Storage
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children. Reconstituted suspension stable for 5-10 days at room temperature, depending on formulation.
Overdose
Symptoms of overdose typically include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures, gastric lavage, and monitoring of vital signs.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, use in pregnancy only if clearly needed. Azithromycin is excreted in human milk; use with caution during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the manufacturing date, consult package for exact expiry.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Azithromycin has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections in both adult and pediatric populations.
Lab Monitoring
- Liver function tests (LFTs) if prolonged use or pre-existing hepatic impairment.
- Renal function tests if severe renal impairment.
- INR/PT if co-administered with warfarin.
Doctor Notes
- Emphasize the importance of completing the full course of antibiotics to prevent resistance.
- Advise patients on potential gastrointestinal side effects and ways to mitigate them (e.g., taking with food).
- Caution about potential drug interactions, especially with warfarin and QT-prolonging agents.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve, to prevent resistance.
- Do not share this medication with others.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Azithromycin may cause dizziness or visual disturbances in some individuals. Exercise caution when driving or operating machinery until you know how the medication affects you.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Get adequate rest to support recovery.
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Global Brand Names
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