Zoclast
Generic Name
Zoclast
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zoclast 4 mg injection | ৳ 6,500.00 | N/A |
Description
Overview of the medicine
Zoclast is a bisphosphonate used for the treatment and prevention of osteoporosis, particularly in postmenopausal women. It helps to increase bone mineral density and reduce the risk of fractures by slowing bone loss.
Uses & Indications
Dosage
Adults
For osteoporosis: 70 mg once weekly, or 10 mg once daily. For Paget's disease: 40 mg once daily for six months.
Elderly
No dosage adjustment required.
Renal_impairment
Not recommended for patients with creatinine clearance less than 35 mL/min.
How to Take
Take Zoclast with a full glass of plain water (not mineral water or other beverages) at least 30 minutes before the first food, beverage, or medication of the day. Do not lie down for at least 30 minutes after taking the dose, and remain upright. Do not chew or suck the tablet.
Mechanism of Action
Zoclast selectively inhibits the activity of osteoclasts, the cells responsible for bone resorption. It binds to bone hydroxyapatite crystals, preventing their dissolution and thereby reducing bone breakdown.
Pharmacokinetics
Onset
Clinical effects on bone density are typically observed within 3-6 months.
Excretion
Primarily excreted unchanged by the kidneys.
Half life
Terminal half-life is greater than 10 years, as it is retained in the bone.
Absorption
Very low (approximately 0.64%) when taken orally on an empty stomach.
Metabolism
Not metabolized in humans.
Side Effects
Contraindications
- Abnormalities of the esophagus which delay esophageal emptying (e.g., stricture or achalasia).
- Inability to stand or sit upright for at least 30 minutes.
- Hypocalcemia.
- Severe renal impairment (creatinine clearance < 35 mL/min).
- Hypersensitivity to any component of the product.
Drug Interactions
NSAIDs
Concomitant use with NSAIDs may increase the risk of gastrointestinal irritation.
Calcium supplements, antacids
May interfere with the absorption of Zoclast. Take Zoclast at least 30 minutes before other oral medications.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events such as upset stomach, heartburn, esophagitis, gastritis, or ulcer. Management involves milk or antacids to bind Zoclast, and symptomatic treatment.
Pregnancy & Lactation
Zoclast is generally not recommended during pregnancy or lactation due to lack of adequate data and potential for fetal harm. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Side Effects
Contraindications
- Abnormalities of the esophagus which delay esophageal emptying (e.g., stricture or achalasia).
- Inability to stand or sit upright for at least 30 minutes.
- Hypocalcemia.
- Severe renal impairment (creatinine clearance < 35 mL/min).
- Hypersensitivity to any component of the product.
Drug Interactions
NSAIDs
Concomitant use with NSAIDs may increase the risk of gastrointestinal irritation.
Calcium supplements, antacids
May interfere with the absorption of Zoclast. Take Zoclast at least 30 minutes before other oral medications.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events such as upset stomach, heartburn, esophagitis, gastritis, or ulcer. Management involves milk or antacids to bind Zoclast, and symptomatic treatment.
Pregnancy & Lactation
Zoclast is generally not recommended during pregnancy or lactation due to lack of adequate data and potential for fetal harm. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, specific details on packaging.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent Expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy of Zoclast in increasing bone mineral density and reducing the incidence of vertebral and hip fractures in postmenopausal women with osteoporosis.
Lab Monitoring
- Serum calcium and phosphate levels should be monitored.
- Vitamin D status should be assessed and corrected if deficient.
- Renal function tests (creatinine clearance) periodically.
Doctor Notes
- Emphasize proper patient education on administration technique to minimize esophageal adverse events.
- Monitor for hypocalcemia before starting treatment and periodically thereafter.
- Consider a 'drug holiday' after 5 years of stable treatment, especially in low-risk patients.
Patient Guidelines
- Take the tablet with plain water only.
- Remain upright for at least 30-60 minutes after taking the dose.
- Do not take with food, beverages (other than plain water), or other medicines.
- Report any new or unusual pain in your thigh, hip, or groin.
Missed Dose Advice
If you miss a weekly dose, take one tablet on the morning after you remember. Do not take two tablets on the same day. Resume your usual schedule. If you miss a daily dose, skip the missed dose and continue with your regular schedule.
Driving Precautions
Zoclast is not known to affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain adequate intake of calcium and Vitamin D through diet or supplements.
- Engage in regular weight-bearing exercise.
- Avoid smoking and excessive alcohol consumption.
- Regularly consult with your doctor regarding bone health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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