Zocort
Generic Name
Hydrocortisone 1% Cream
Manufacturer
Local Pharma Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zocort 1 cream | ৳ 70.00 | N/A |
Description
Overview of the medicine
Zocort-1 Cream contains hydrocortisone, a corticosteroid used to reduce inflammation, itching, and redness associated with various skin conditions.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area 2 to 4 times daily, as directed by a physician.
Elderly
No specific dosage adjustment required; use with caution due to potential for thinner skin and increased absorption.
Renal_impairment
Not applicable for topical use; systemic absorption is minimal.
How to Take
For external use only. Apply thinly to the affected area and rub in gently. Do not cover with occlusive dressings unless advised by a doctor. Wash hands before and after application.
Mechanism of Action
Hydrocortisone is a corticosteroid that acts by diffusing across cell membranes and binding to specific cytoplasmic receptors. These complexes then enter the nucleus, bind to DNA, and modify gene expression to produce anti-inflammatory, antipruritic, and vasoconstrictive effects.
Pharmacokinetics
Onset
Hours to days for noticeable effect
Excretion
Mainly renal as inactive metabolites.
Half life
Varies by route and formulation, systemic half-life about 8-12 hours for hydrocortisone but topical action is localized.
Absorption
Minimal systemic absorption through intact skin; increased absorption with occlusion, inflammation, or prolonged use.
Metabolism
Primarily hepatic, converted to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to hydrocortisone or any component of the cream
- Fungal, viral, or bacterial skin infections (untreated)
- Perioral dermatitis
- Rosacea
- Acne
Drug Interactions
No significant drug interactions reported with topical hydrocortisone 1% due to minimal systemic absorption.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with topical application is unlikely. Chronic overuse may lead to systemic effects of corticosteroids, such as Cushing's syndrome.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a doctor. Limited data on excretion in breast milk; use with caution.
Side Effects
Contraindications
- Hypersensitivity to hydrocortisone or any component of the cream
- Fungal, viral, or bacterial skin infections (untreated)
- Perioral dermatitis
- Rosacea
- Acne
Drug Interactions
No significant drug interactions reported with topical hydrocortisone 1% due to minimal systemic absorption.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with topical application is unlikely. Chronic overuse may lead to systemic effects of corticosteroids, such as Cushing's syndrome.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a doctor. Limited data on excretion in breast milk; use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date, refer to packaging for exact details.
Availability
Pharmacies, drugstores
Approval Status
Approved by regulatory bodies for topical use
Patent Status
Generally off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials support the efficacy and safety of topical hydrocortisone for corticosteroid-responsive dermatoses.
Lab Monitoring
- Not typically required for short-term topical use. For extensive or prolonged use, monitoring for systemic corticosteroid effects might be considered (e.g., HPA axis suppression).
Doctor Notes
- Advise patients on appropriate application technique and duration of use.
- Warn about potential for skin thinning, especially on face or intertriginous areas.
- Consider lower potency corticosteroids for long-term or delicate area use.
- Educate on signs of infection and when to seek further medical advice.
Patient Guidelines
- Apply sparingly to the affected area.
- Avoid contact with eyes, mouth, and other mucous membranes.
- Do not use for longer than prescribed by your doctor.
- Inform your doctor if your condition worsens or does not improve.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra to make up for a missed dose.
Driving Precautions
No known effects on ability to drive or operate machinery for topical use.
Lifestyle Advice
- Keep the affected area clean and dry.
- Avoid irritants that may worsen your skin condition.
- Wear loose-fitting clothing over treated areas.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.