Zolibac
Generic Name
Cefixime
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zolibac 1 gm injection | ৳ 200.00 | N/A |
Description
Overview of the medicine
Zolibac (Cefixime) is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including those of the ear, nose, throat, lower respiratory tract, urinary tract, and uncomplicated gonorrhea.
Uses & Indications
Dosage
Adults
Adults and children over 12 years or weighing >50 kg: 200-400 mg once daily or 200 mg twice daily, depending on the severity of infection.
Elderly
No dose adjustment needed unless severe renal impairment.
Renal_impairment
CrCl 21-60 mL/min: 75% of standard dose. CrCl <20 mL/min: 50% of standard dose.
How to Take
Can be taken with or without food. For oral suspension, shake well before use. Complete the full course of medication even if symptoms improve.
Mechanism of Action
Cefixime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to lysis and death of bacterial cells.
Pharmacokinetics
Onset
Peak plasma concentrations reached in 2-6 hours.
Excretion
Mainly renal (approximately 50% unchanged in urine), and some biliary excretion.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% absorbed orally. Food may delay absorption but does not significantly affect the extent.
Metabolism
Not extensively metabolized. Primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reactions to penicillin
Drug Interactions
Warfarin
Increased prothrombin time (INR) with concurrent use, requiring INR monitoring.
Probenecid
Increases cefixime plasma levels and prolongs half-life.
Carbamazepine
Increased carbamazepine levels.
Oral Contraceptives
May decrease efficacy of oral contraceptives (use alternative contraception).
Storage
Store at room temperature (below 30°C), protect from light and moisture. Keep reconstituted suspension refrigerated (2-8°C).
Overdose
Symptoms may include nausea, vomiting, diarrhea, and central nervous system toxicity. Treatment is supportive; hemodialysis or peritoneal dialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reactions to penicillin
Drug Interactions
Warfarin
Increased prothrombin time (INR) with concurrent use, requiring INR monitoring.
Probenecid
Increases cefixime plasma levels and prolongs half-life.
Carbamazepine
Increased carbamazepine levels.
Oral Contraceptives
May decrease efficacy of oral contraceptives (use alternative contraception).
Storage
Store at room temperature (below 30°C), protect from light and moisture. Keep reconstituted suspension refrigerated (2-8°C).
Overdose
Symptoms may include nausea, vomiting, diarrhea, and central nervous system toxicity. Treatment is supportive; hemodialysis or peritoneal dialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for tablets/capsules; reconstituted suspension typically 7-14 days.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety profile against various bacterial infections.
Lab Monitoring
- Renal function tests (e.g., BUN, creatinine) in prolonged therapy or in patients with pre-existing renal impairment.
- INR monitoring if co-administered with warfarin.
Doctor Notes
- Monitor renal function in elderly and patients with pre-existing renal impairment.
- Counsel patients on completing the full course to prevent resistance.
Patient Guidelines
- Take as prescribed, do not skip doses.
- Complete the full course of antibiotic.
- Report any severe diarrhea or allergic reactions immediately.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair ability to drive or operate machinery. However, if dizziness occurs, exercise caution.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment.
- Report any persistent side effects.
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Global Brand Names
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