Zolmit
Generic Name
Zolmitriptan
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zolmit 25 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Zolmitriptan is a selective serotonin (5-HT1B/1D) receptor agonist indicated for the acute treatment of migraine with or without aura in adults.
Uses & Indications
Dosage
Adults
The recommended initial dose is 2.5 mg. If symptoms persist or recur, a second dose may be taken after 2 hours. Maximum dose is 10 mg in any 24-hour period.
Elderly
No dosage adjustment is required, but caution is advised in patients over 65 years due to potential cardiovascular risk.
Renal_impairment
No dosage adjustment is required for mild to moderate renal impairment. Use with caution in severe renal impairment (creatinine clearance < 15 mL/min).
How to Take
Take the tablet whole with water, with or without food, as soon as migraine symptoms appear. Do not use for migraine prevention.
Mechanism of Action
Zolmitriptan binds to 5-HT1B and 5-HT1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system. It causes cranial vasoconstriction, inhibits the release of inflammatory neuropeptides, and blocks pain pathways, thereby alleviating migraine symptoms.
Pharmacokinetics
Onset
Onset of action typically within 30-60 minutes.
Excretion
Primarily renal (approximately 60-65%), with some fecal excretion (approximately 30-40%).
Half life
Approximately 2.5-3 hours for zolmitriptan; 4.5-5.7 hours for active metabolite.
Absorption
Rapidly and well absorbed after oral administration. Absolute bioavailability is approximately 40%.
Metabolism
Hepatic metabolism, primarily by CYP1A2, to an active N-desmethyl metabolite and inactive metabolites.
Side Effects
Contraindications
- Ischaemic heart disease (angina pectoris, myocardial infarction, documented silent ischaemia)
- History of stroke or transient ischaemic attack (TIA)
- Peripheral vascular disease
- Uncontrolled hypertension
- Basilar or hemiplegic migraine
- Concomitant use with other 5-HT1B/1D agonists, ergotamine-containing preparations, or MAOIs
- Severe hepatic impairment
Drug Interactions
MAOIs
Increases plasma concentrations of zolmitriptan. Avoid concomitant use.
Cimetidine
Increases plasma concentrations and half-life of zolmitriptan. Reduce zolmitriptan dose if necessary.
SSRIs/SNRIs
Potential for serotonin syndrome (rare but serious). Monitor patients if co-administered.
Ergotamine-containing preparations and other 5-HT1B/1D agonists
Increased risk of vasospastic reactions. Avoid co-administration within 24 hours of each other.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include sedation, ataxia, and hypotension. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Zolmitriptan is excreted into breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Ischaemic heart disease (angina pectoris, myocardial infarction, documented silent ischaemia)
- History of stroke or transient ischaemic attack (TIA)
- Peripheral vascular disease
- Uncontrolled hypertension
- Basilar or hemiplegic migraine
- Concomitant use with other 5-HT1B/1D agonists, ergotamine-containing preparations, or MAOIs
- Severe hepatic impairment
Drug Interactions
MAOIs
Increases plasma concentrations of zolmitriptan. Avoid concomitant use.
Cimetidine
Increases plasma concentrations and half-life of zolmitriptan. Reduce zolmitriptan dose if necessary.
SSRIs/SNRIs
Potential for serotonin syndrome (rare but serious). Monitor patients if co-administered.
Ergotamine-containing preparations and other 5-HT1B/1D agonists
Increased risk of vasospastic reactions. Avoid co-administration within 24 hours of each other.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include sedation, ataxia, and hypotension. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Zolmitriptan is excreted into breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored correctly.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Zolmitriptan has been extensively studied in numerous randomized, double-blind, placebo-controlled clinical trials demonstrating its efficacy and safety in the acute treatment of migraine.
Lab Monitoring
- No routine laboratory monitoring is typically required for Zolmitriptan.
Doctor Notes
- Prior to prescribing, assess patient for cardiovascular risk factors and rule out underlying cardiovascular disease.
- Educate patients on the signs and symptoms of serotonin syndrome when co-administering with SSRIs/SNRIs.
- Advise patients not to exceed recommended doses to prevent medication overuse headache.
Patient Guidelines
- Take Zolmitriptan only when a migraine headache has started.
- Do not take more than 10 mg within 24 hours.
- Do not use for migraine prevention or for types of headaches other than migraine.
Missed Dose Advice
Since Zolmitriptan is used for acute treatment, there is no missed dose. Take it only when a migraine attack occurs.
Driving Precautions
Zolmitriptan may cause dizziness, somnolence, or other symptoms that could impair the ability to drive or operate machinery. Patients should be cautious.
Lifestyle Advice
- Identify and avoid personal migraine triggers.
- Maintain a regular sleep schedule and reduce stress.
- Engage in regular physical activity as tolerated.
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Global Brand Names
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