Zovia-Silver
Generic Name
Ethynodiol Diacetate + Ethinyl Estradiol (with Iron)
Manufacturer
Acme Pharmaceuticals
Country
Varies by manufacturer, commonly India, USA, Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zovia silver tablet | ৳ 10.50 | ৳ 315.00 |
Description
Overview of the medicine
Zovia-Silver is a combined oral contraceptive tablet containing ethynodiol diacetate (a progestin) and ethinyl estradiol (an estrogen), often with iron supplements in the inactive pills, used primarily to prevent pregnancy.
Uses & Indications
Dosage
Adults
One tablet orally once daily at the same time each day for 21 or 24 consecutive days, followed by 7 or 4 days of inactive/iron-containing tablets, depending on the specific pack regimen.
Elderly
Not indicated for postmenopausal women.
Renal_impairment
No specific dose adjustment for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take one tablet orally at the same time each day. Start with the first active tablet on the first day of menstruation or the first Sunday after menstruation begins. Follow the arrows on the pack.
Mechanism of Action
Primarily suppresses ovulation, thickens cervical mucus to prevent sperm penetration, and alters the endometrium to inhibit implantation.
Pharmacokinetics
Onset
Contraceptive effect usually starts after 7 consecutive days of active pill use in the first cycle.
Excretion
Excreted primarily in urine and feces as metabolites.
Half life
Ethinyl Estradiol: 13-27 hours; Norethindrone (active metabolite of Ethynodiol Diacetate): 5-14 hours.
Absorption
Rapidly absorbed after oral administration. Ethynodiol diacetate is rapidly deacylated to norethindrone which is then metabolized.
Metabolism
Both hormones undergo extensive first-pass metabolism in the liver. Ethinyl estradiol is primarily metabolized via CYP3A4. Ethynodiol diacetate is converted to norethindrone and then metabolized further.
Side Effects
Contraindications
- •History of thrombosis or thromboembolic disorders
- •Severe liver disease
- •Undiagnosed abnormal uterine bleeding
- •Known or suspected breast cancer or other estrogen-dependent neoplasia
- •Pregnancy
- •Migraine with aura
Drug Interactions
Rifampicin
Decreased contraceptive efficacy
Griseofulvin
Decreased contraceptive efficacy
St. John's Wort
Decreased contraceptive efficacy
Ritonavir/Cobicistat
Altered hormone levels, decreased efficacy
Anticonvulsants (e.g., carbamazepine, phenytoin)
Decreased contraceptive efficacy
Storage
Store at room temperature (20-25°C), away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, and withdrawal bleeding. Treatment is symptomatic and supportive; no specific antidote.
Pregnancy & Lactation
Contraindicated during pregnancy. Use during lactation may reduce milk production and alter milk composition; small amounts of steroids are excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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