Zuracin
Generic Name
Cefuroxime Axetil
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zuracin 125 mg suspension | ৳ 61.00 | N/A |
Description
Overview of the medicine
Zuracin 125 mg Suspension contains Cefuroxime Axetil, a second-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections including respiratory tract infections, skin and soft tissue infections, and urinary tract infections.
Uses & Indications
Dosage
Adults
250-500 mg (10-20 ml of 125 mg/5 ml suspension) twice daily depending on infection severity and type.
Elderly
Similar to adults, but renal function should be considered for dose adjustment.
Renal_impairment
Creatinine clearance 10-29 mL/min: 125-250 mg every 24 hours. Creatinine clearance <10 mL/min: 125-250 mg every 48 hours.
How to Take
Administer orally. Shake the bottle well before each use. For optimal absorption, it is recommended to take Cefuroxime Axetil suspension with food.
Mechanism of Action
Cefuroxime Axetil is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to lysis and death of the bacterial cell.
Pharmacokinetics
Onset
1-2 hours
Excretion
Primarily via the kidneys, mainly as unchanged drug.
Half life
Approximately 1.2 to 1.5 hours
Absorption
Well absorbed after oral administration, enhanced with food.
Metabolism
Hydrolyzed by esterases in the intestinal mucosa and blood to active cefuroxime.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime or any other cephalosporin antibiotics
- History of severe hypersensitivity reactions to beta-lactam antibiotics (e.g., penicillins)
Drug Interactions
Antacids
May decrease the bioavailability of cefuroxime. Administer at least 1 hour before or 2 hours after antacids.
Probenecid
Increases and prolongs serum concentrations of cefuroxime by reducing renal tubular secretion.
Oral Contraceptives
May decrease the efficacy of oral contraceptives; advise using alternative birth control methods.
Storage
Store dry powder below 30°C. Keep away from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after 10 days. Do not freeze.
Overdose
Overdose symptoms may include cerebral irritation leading to convulsions. Treatment is symptomatic and supportive. Hemodialysis can reduce serum cefuroxime levels.
Pregnancy & Lactation
Pregnancy Category B. While studies in animals have not shown harm, adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime or any other cephalosporin antibiotics
- History of severe hypersensitivity reactions to beta-lactam antibiotics (e.g., penicillins)
Drug Interactions
Antacids
May decrease the bioavailability of cefuroxime. Administer at least 1 hour before or 2 hours after antacids.
Probenecid
Increases and prolongs serum concentrations of cefuroxime by reducing renal tubular secretion.
Oral Contraceptives
May decrease the efficacy of oral contraceptives; advise using alternative birth control methods.
Storage
Store dry powder below 30°C. Keep away from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after 10 days. Do not freeze.
Overdose
Overdose symptoms may include cerebral irritation leading to convulsions. Treatment is symptomatic and supportive. Hemodialysis can reduce serum cefuroxime levels.
Pregnancy & Lactation
Pregnancy Category B. While studies in animals have not shown harm, adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefuroxime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unreconstituted powder: 2 years. Reconstituted suspension: 10 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of cefuroxime axetil in various bacterial infections. Ongoing research continues to monitor resistance patterns and optimize usage.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) especially in patients with pre-existing renal impairment or during prolonged high-dose therapy.
- Hepatic function tests (e.g., ALT, AST) if signs of liver dysfunction develop or during prolonged therapy.
- Complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Confirm bacterial etiology before prescribing antibiotics.
- Adjust dose in renal impairment.
- Counsel patients on completing the full course to prevent resistance.
- Monitor for signs of _Clostridioides difficile_ infection.
Patient Guidelines
- Take the entire course of medicine as prescribed, even if you feel better.
- Shake the suspension bottle well before each dose.
- Take with food to enhance absorption and reduce stomach upset.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor about any allergic reactions or severe side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefuroxime Axetil may cause dizziness. Patients should be advised to exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol during treatment as it may exacerbate stomach upset.
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