Zypred
Generic Name
Prednisolone Acetate
Manufacturer
Allergan, Inc. (an AbbVie Company)
Country
United States
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| zypred 05 03 suspension | ৳ 290.00 | N/A |
Description
Overview of the medicine
Zypred (prednisolone acetate ophthalmic suspension) is a corticosteroid medication used to treat inflammation of the eye (e.g., uveitis, allergic conjunctivitis, keratitis).
Uses & Indications
Dosage
Adults
Instill 1 or 2 drops into the conjunctival sac 2 to 4 times daily. During the initial 24 to 48 hours, the dosage may be safely increased to 2 drops every hour. Care should be taken not to discontinue therapy prematurely.
Elderly
No specific dosage adjustment required.
Renal_impairment
Not applicable for topical ophthalmic use as systemic absorption is minimal.
How to Take
Shake well before use. Apply drops directly into the conjunctival sac. Avoid touching the dropper tip to the eye or any other surface.
Mechanism of Action
Prednisolone acetate acts by inhibiting the inflammatory response to a variety of agents and may delay or slow healing. It stabilizes lysosomal membranes, prevents the release of destructive acid hydrolases from leukocytes; inhibits macrophage accumulation in inflamed areas; reduces adhesion of leukocytes to capillary endothelium; reduces leakage of capillaries; inhibits fibroblast formation; reduces collagen deposition; and stabilizes cellular and subcellular membranes.
Pharmacokinetics
Onset
Within a few hours for anti-inflammatory effects.
Excretion
Excreted mainly in the urine.
Half life
Systemic half-life of prednisolone is 2-4 hours, but topical ocular action is localized.
Absorption
Minimal systemic absorption when applied topically to the eye. Local absorption into ocular tissues.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Acute untreated purulent bacterial infections
- Fungal infections of ocular structures
- Most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella
- Mycobacterial infection of the eye
- Hypersensitivity to any component of the medication
Drug Interactions
Systemic CYP3A4 inhibitors
While systemic absorption is minimal, potent CYP3A4 inhibitors could potentially increase systemic levels if significant absorption occurs. (Generally not clinically significant for topical ophthalmic use)
Other topical ophthalmic medications
If using multiple ophthalmic medications, administer them at least 5 minutes apart.
Storage
Store upright at 15°C to 25°C (59°F to 77°F). Protect from freezing.
Overdose
Unlikely with topical ophthalmic administration. If accidentally ingested, symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Pregnancy: Category C. Use only if the potential benefit justifies the potential risk to the fetus. Lactation: It is unknown whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Exercise caution.
Side Effects
Contraindications
- Acute untreated purulent bacterial infections
- Fungal infections of ocular structures
- Most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella
- Mycobacterial infection of the eye
- Hypersensitivity to any component of the medication
Drug Interactions
Systemic CYP3A4 inhibitors
While systemic absorption is minimal, potent CYP3A4 inhibitors could potentially increase systemic levels if significant absorption occurs. (Generally not clinically significant for topical ophthalmic use)
Other topical ophthalmic medications
If using multiple ophthalmic medications, administer them at least 5 minutes apart.
Storage
Store upright at 15°C to 25°C (59°F to 77°F). Protect from freezing.
Overdose
Unlikely with topical ophthalmic administration. If accidentally ingested, symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Pregnancy: Category C. Use only if the potential benefit justifies the potential risk to the fetus. Lactation: It is unknown whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Exercise caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 18-24 months unopened. Discard 28 days after opening.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Prednisolone acetate ophthalmic suspension has been extensively studied and widely used for decades in various clinical trials demonstrating its efficacy in treating ocular inflammation.
Lab Monitoring
- Periodic measurement of intraocular pressure (IOP) should be performed if used for 10 days or longer.
Doctor Notes
- Caution in patients with glaucoma or ocular hypertension.
- Avoid prolonged use without monitoring intraocular pressure.
- Contraindicated in active viral, fungal, or mycobacterial eye infections.
- Sterilize dropper tip before use.
Patient Guidelines
- Shake bottle well before each use.
- Do not touch the dropper tip to any surface to avoid contamination.
- Remove contact lenses before use and wait at least 15 minutes before reinserting.
- Inform your doctor if your condition worsens or does not improve after a few days.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not use extra medicine to make up for a missed dose.
Driving Precautions
May cause temporary blurred vision after application. Exercise caution when driving or operating machinery until vision is clear.
Lifestyle Advice
- Avoid rubbing your eyes.
- Limit screen time if experiencing blurred vision or discomfort.
- Wear sunglasses if light sensitivity occurs.
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