Aceclofenac
Generic Name
Aceclofenac 100 mg Tablet
Manufacturer
Various Generic Manufacturers
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aceclofenac 100 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Uses & Indications
Dosage
Adults
100 mg twice daily, preferably with or after food. The maximum recommended daily dose is 200 mg.
Elderly
Generally, the same dosage as adults, but caution should be exercised and dose adjustment may be considered due to potential for renal or hepatic impairment.
Renal_impairment
Caution is advised. Lower initial doses and careful monitoring are recommended for mild to moderate renal impairment. Contraindicated in severe renal impairment.
How to Take
Take orally, swallow the tablet whole with a sufficient amount of water. It is recommended to take aceclofenac with or immediately after food to reduce gastrointestinal discomfort.
Mechanism of Action
Aceclofenac primarily acts by inhibiting the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins, mediators of pain and inflammation. It has a preferential inhibitory effect on COX-2.
Pharmacokinetics
Onset
Within 1-2 hours for analgesic effects.
Excretion
Approximately two-thirds of the dose is excreted in the urine and one-third in the faeces as hydroxylated metabolites.
Half life
Approximately 4-4.3 hours.
Absorption
Well absorbed orally, peak plasma concentrations reached in 1.25 to 3 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9, to 4'-hydroxyaceclofenac and diclofenac.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs (e.g., aspirin-induced asthma, urticaria, acute rhinitis)
- Active gastrointestinal bleeding or peptic ulcer/hemorrhage (history of recurrent ulceration)
- Severe heart failure, severe renal impairment, or severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, and rarely diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, fainting, and convulsions. In cases of significant poisoning, acute renal failure and liver damage are possible. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal if ingestion was recent.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential for premature closure of the ductus arteriosus and impaired renal function in the fetus. Should be avoided during the first two trimesters unless absolutely necessary. Use with caution during lactation; small amounts may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs (e.g., aspirin-induced asthma, urticaria, acute rhinitis)
- Active gastrointestinal bleeding or peptic ulcer/hemorrhage (history of recurrent ulceration)
- Severe heart failure, severe renal impairment, or severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, and rarely diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, fainting, and convulsions. In cases of significant poisoning, acute renal failure and liver damage are possible. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal if ingestion was recent.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential for premature closure of the ductus arteriosus and impaired renal function in the fetus. Should be avoided during the first two trimesters unless absolutely necessary. Use with caution during lactation; small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date, depending on manufacturer.
Availability
Pharmacies, hospitals
Approval Status
Approved (e.g., by DGDA in Bangladesh)
Patent Status
Generic available
Clinical Trials
Aceclofenac has undergone numerous clinical trials demonstrating its efficacy and safety in various inflammatory conditions. Ongoing research may explore new formulations or specific patient populations.
Lab Monitoring
- Liver function tests (e.g., ALT, AST) particularly with long-term use
- Kidney function tests (e.g., serum creatinine, BUN) particularly with long-term use or in elderly patients
- Complete blood count (CBC) for signs of anemia or blood dyscrasias
Doctor Notes
- Assess cardiovascular and gastrointestinal risk factors before prescribing, especially for long-term therapy.
- Consider co-prescribing a proton pump inhibitor (PPI) for patients at high risk of GI complications.
- Monitor renal and hepatic function, and blood pressure periodically during long-term treatment.
- Advise patients on symptoms of GI bleeding or cardiovascular events and when to seek immediate medical attention.
Patient Guidelines
- Take aceclofenac exactly as prescribed by your doctor.
- Always take with or after food to minimize stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about any other medications you are taking, especially blood thinners or other NSAIDs.
- Report any unusual side effects like stomach pain, black stools, or unusual bruising to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Aceclofenac may cause dizziness or visual disturbances in some patients. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol while taking this medicine as it may increase the risk of stomach problems.
- Maintain adequate hydration, especially if you have kidney issues.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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