Acitrin
Generic Name
Cetirizine Hydrochloride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acitrin 25 mg pediatric drop | ৳ 25.08 | N/A |
Description
Overview of the medicine
Acitrin 2.5 mg/mL Pediatric Drop contains Cetirizine, a second-generation H1-receptor antagonist. It is used to relieve symptoms associated with seasonal and perennial allergic rhinitis, and chronic idiopathic urticaria in children. The '25 mg' in the product name typically refers to the total cetirizine content in a 10 mL bottle.
Uses & Indications
Dosage
Adults
Acitrin Pediatric Drop is formulated for children. Adults typically use tablet formulations, usually 10 mg once daily.
Elderly
Acitrin Pediatric Drop is formulated for children. Elderly patients typically use tablet formulations, with potential dose adjustments for renal function.
Renal_impairment
For pediatric patients with renal impairment, the dose should be individualized and significantly reduced. Consult a physician for specific guidance.
How to Take
Administer orally using the calibrated dropper provided. The drops can be taken with or without food. Ensure accurate measurement of the prescribed dose.
Mechanism of Action
Cetirizine, the active ingredient in Acitrin, is a potent selective peripheral H1-receptor antagonist. It works by preventing histamine from binding to H1-receptors, thereby inhibiting the release of other inflammatory mediators and reducing allergy symptoms such as sneezing, runny nose, and itching.
Pharmacokinetics
Onset
Within 20-60 minutes.
Excretion
Primarily excreted unchanged in urine (about 70% within 24 hours), and a small amount in feces.
Half life
Approximately 6-10 hours in adults; shorter in children (e.g., 5-6 hours in 6-12 years, 2-5 hours in 0.5-2 years).
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1 hour. Food may delay absorption but does not affect the extent of absorption.
Metabolism
Minimal hepatic metabolism (less than 10% of the dose is metabolized).
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivative
- Severe renal impairment (Creatinine Clearance < 10 mL/min)
- Children under 6 months of age (unless advised by a physician)
Drug Interactions
Theophylline (low dose)
A slight decrease in cetirizine clearance has been observed, but dose adjustment is generally not necessary.
Central nervous system depressants (e.g., alcohol, sedatives)
Concomitant use may increase CNS depression (e.g., drowsiness).
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep the bottle tightly closed. Do not freeze.
Overdose
Symptoms of overdose may include drowsiness, sedation, tachycardia, urinary retention, and tremor. Management is symptomatic and supportive. There is no specific antidote. Gastric lavage may be considered soon after ingestion, and activated charcoal may be administered.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cetirizine is excreted in breast milk, so caution is advised when administered to a nursing mother. Consult a physician.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivative
- Severe renal impairment (Creatinine Clearance < 10 mL/min)
- Children under 6 months of age (unless advised by a physician)
Drug Interactions
Theophylline (low dose)
A slight decrease in cetirizine clearance has been observed, but dose adjustment is generally not necessary.
Central nervous system depressants (e.g., alcohol, sedatives)
Concomitant use may increase CNS depression (e.g., drowsiness).
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep the bottle tightly closed. Do not freeze.
Overdose
Symptoms of overdose may include drowsiness, sedation, tachycardia, urinary retention, and tremor. Management is symptomatic and supportive. There is no specific antidote. Gastric lavage may be considered soon after ingestion, and activated charcoal may be administered.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cetirizine is excreted in breast milk, so caution is advised when administered to a nursing mother. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture. Refer to the specific product packaging for the exact expiry date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cetirizine has been extensively evaluated in numerous clinical trials, including studies in pediatric populations, demonstrating its efficacy and safety for various allergic conditions.
Lab Monitoring
- No specific routine laboratory monitoring is required for Cetirizine. Renal function should be monitored in pediatric patients with pre-existing renal impairment who are receiving chronic therapy.
Doctor Notes
- Educate parents/caregivers on the importance of accurate dosing using the calibrated dropper and not exceeding the prescribed dose.
- Monitor pediatric patients, especially younger children, for excessive sedation or paradoxical excitation.
- Consider dose adjustment in pediatric patients with impaired renal function, even for chronic therapy.
Patient Guidelines
- Always use the calibrated dropper provided with the medication for accurate dosing.
- Do not exceed the recommended dose, as this may increase side effects.
- Store the medicine out of reach and sight of children.
- Consult a doctor if your child's symptoms persist or worsen after taking the medicine.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This product is specifically for pediatric use. However, caregivers should be aware that cetirizine can cause drowsiness or dizziness in children, which may affect their ability to participate in activities requiring mental alertness.
Lifestyle Advice
- Identify and avoid known allergens that trigger allergic reactions in your child.
- Ensure adequate hydration for your child, especially during allergic episodes.
- Maintain good indoor air quality.
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