Acitrin
Generic Name
Cetirizine Hydrochloride
Manufacturer
General Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acitrin 5 mg syrup | ৳ 34.00 | N/A |
Description
Overview of the medicine
Acitrin 5 mg syrup contains Cetirizine Hydrochloride, an antihistamine used to relieve symptoms of allergic conditions such as hay fever, conjunctivitis, and skin rashes. It is primarily used for children and adolescents.
Uses & Indications
Dosage
Adults
Adults and adolescents 12 years and older: 10 mg (10 ml) once daily, usually with a 10 mg tablet, or 5 ml (5 mg) twice daily for syrup. Children 6-11 years: 5 mg (5 ml) once daily. Children 2-5 years: 2.5 mg (2.5 ml) once daily; may be increased to 5 mg (5 ml) once daily in divided doses or as a single dose. Infants under 2 years: Consult a pediatrician.
Elderly
No dose adjustment required in elderly patients with normal renal function. For renal impairment, see below.
Renal_impairment
Moderate renal impairment (creatinine clearance 31-50 ml/min): 5 mg (5 ml) once daily. Severe renal impairment (creatinine clearance < 30 ml/min): 5 mg (5 ml) every other day.
How to Take
Oral administration. Measure the dose accurately using the provided measuring spoon or oral syringe. Can be taken with or without food.
Mechanism of Action
Cetirizine is a potent and highly selective H1-receptor antagonist. It works by blocking histamine, a natural substance that the body produces during an allergic reaction, thereby reducing allergy symptoms.
Pharmacokinetics
Onset
Within 20-60 minutes
Excretion
Mainly excreted in urine, largely as unchanged drug.
Half life
Approximately 8-11 hours in adults
Absorption
Rapidly absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are achieved within 1 hour.
Metabolism
Undergoes limited hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives
- Patients with severe renal impairment (creatinine clearance <10 ml/min)
Drug Interactions
Theophylline
Decreased cetirizine clearance, increased adverse effects.
CNS Depressants (e.g., alcohol, sedatives)
Increased CNS depression, drowsiness. Avoid concomitant use.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include drowsiness, sedation, tachycardia, urinary retention. Management involves symptomatic and supportive treatment. Gastric lavage may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted into breast milk, so use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives
- Patients with severe renal impairment (creatinine clearance <10 ml/min)
Drug Interactions
Theophylline
Decreased cetirizine clearance, increased adverse effects.
CNS Depressants (e.g., alcohol, sedatives)
Increased CNS depression, drowsiness. Avoid concomitant use.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include drowsiness, sedation, tachycardia, urinary retention. Management involves symptomatic and supportive treatment. Gastric lavage may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted into breast milk, so use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date, refer to product label.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established cetirizine's efficacy and safety in allergic conditions.
Lab Monitoring
- No specific routine lab monitoring required. Renal function monitoring in patients with kidney impairment.
Doctor Notes
- Advise patients on potential for drowsiness and avoidance of activities requiring alertness.
- Counsel on proper dosage measurement, especially for pediatric use.
- Consider renal function in elderly and renally impaired patients.
Patient Guidelines
- Do not exceed the recommended dose.
- This medicine may cause drowsiness, avoid driving or operating heavy machinery until you know how it affects you.
- Inform your doctor if symptoms do not improve or worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Patients should be warned not to engage in activities requiring mental alertness, such as driving a car or operating machinery, until they know how this drug affects them.
Lifestyle Advice
- Avoid alcohol consumption as it may increase drowsiness.
- Identify and avoid known allergens to help manage allergy symptoms.
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