Acos
Generic Name
Azithromycin
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| acos 200 mg suspension | ৳ 190.00 | N/A |
Description
Overview of the medicine
Acos 200 mg Suspension contains Azithromycin, a macrolide antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
Dosage varies by indication. For example, for community-acquired pneumonia, 500 mg orally as a single dose on day 1, then 250 mg once daily on days 2-5. Pediatric dosage: 10 mg/kg once daily for 3 days or 10 mg/kg on day 1, then 5 mg/kg on days 2-5 (for acute otitis media).
Elderly
No dosage adjustment needed for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment (CrCl >10 mL/min). Exercise caution in severe impairment.
How to Take
Oral suspension should be shaken well before use. May be taken with or without food. To maximize absorption, it is sometimes recommended to take Azithromycin suspension on an empty stomach (1 hour before or 2 hours after food), especially for single high doses for specific infections like gonorrhoea or chlamydia. For typical multi-day courses, it can be taken with or without food.
Mechanism of Action
Azithromycin works by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting protein synthesis. This results in bacteriostatic effects, preventing bacterial growth.
Pharmacokinetics
Onset
Typically within 2-3 hours.
Excretion
Primarily excreted unchanged in the bile; a small portion is excreted in urine.
Half life
Terminal elimination half-life is 2-4 days due to extensive tissue uptake and slow release.
Absorption
Rapidly absorbed from the gastrointestinal tract; however, food significantly decreases absorption (oral suspension).
Metabolism
Hepatic metabolism, primarily via demethylation. Not metabolized by CYP450 system to a significant extent.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Digoxin
Increased serum digoxin levels. Monitor digoxin levels.
Warfarin
Increased anticoagulant effect. Monitor INR/PT.
Nelfinavir
Increased azithromycin serum concentrations. Monitor for azithromycin side effects.
Antacids containing aluminum or magnesium
Decreased peak serum levels of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store the dry powder below 30°C, away from moisture and direct light. Once reconstituted, store the suspension at room temperature (20-25°C) and discard after the specified period (e.g., 10 days). Do not refrigerate unless specified by the manufacturer.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Digoxin
Increased serum digoxin levels. Monitor digoxin levels.
Warfarin
Increased anticoagulant effect. Monitor INR/PT.
Nelfinavir
Increased azithromycin serum concentrations. Monitor for azithromycin side effects.
Antacids containing aluminum or magnesium
Decreased peak serum levels of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store the dry powder below 30°C, away from moisture and direct light. Once reconstituted, store the suspension at room temperature (20-25°C) and discard after the specified period (e.g., 10 days). Do not refrigerate unless specified by the manufacturer.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (unreconstituted powder). Reconstituted suspension typically 5-10 days at room temperature.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Azithromycin's efficacy and safety in treating various bacterial infections. Ongoing research explores its anti-inflammatory and immunomodulatory properties.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment)
- Renal function tests (in patients with severe renal impairment)
- INR/PT (if co-administered with warfarin)
- ECG (in patients at risk for QT prolongation)
Doctor Notes
- Counsel patients on proper reconstitution and administration of suspension.
- Advise patients to complete the full course of therapy to prevent resistance.
- Be aware of potential drug interactions, especially with warfarin and drugs known to prolong the QT interval.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Do not share this medication with others.
- Shake the suspension well before each use.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Azithromycin generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain good hydration during treatment.
- Avoid excessive sun exposure due to potential photosensitivity (rare).
- Avoid alcohol if experiencing significant gastrointestinal upset.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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