Action XR
Generic Name
Metformin Hydrochloride (Extended Release)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| action xr 665 mg tablet | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Action XR (Metformin Hydrochloride) is an oral antidiabetic drug used in the management of type 2 diabetes mellitus. It helps control blood sugar levels by decreasing glucose production in the liver, decreasing glucose absorption in the intestines, and improving insulin sensitivity.
Uses & Indications
Dosage
Adults
Initially 500 mg once daily with evening meal, increase gradually to a maximum of 2000 mg once daily. Dosage adjustments should be made based on glycemic control and tolerability.
Elderly
Initiate at the lower end of the dosing range, considering renal function.
Renal_impairment
Use with caution in patients with moderate renal impairment (eGFR 30-45 mL/min/1.73 m²). Contraindicated in severe renal impairment (eGFR < 30 mL/min/1.73 m²).
How to Take
Swallow whole with water. Do not crush, chew, or break the tablet.
Mechanism of Action
Metformin works by reducing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization.
Pharmacokinetics
Onset
Within a few days of starting treatment.
Excretion
Excreted unchanged in the urine.
Half life
Approximately 6 hours.
Absorption
Slow and incomplete absorption from the gastrointestinal tract.
Metabolism
Not metabolized by the liver.
Side Effects
Contraindications
- •Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
- •Metabolic acidosis
- •Hypersensitivity to metformin
Drug Interactions
Alcohol
Increased risk of lactic acidosis.
Insulin and Sulfonylureas
Increased risk of hypoglycemia. Dosage adjustments may be necessary.
Storage
Store at room temperature, away from moisture and heat.
Overdose
Overdose of metformin can lead to lactic acidosis. Immediate medical attention is required.
Pregnancy & Lactation
Metformin is generally not recommended during pregnancy. Insulin is usually preferred for managing gestational diabetes. Consult a healthcare professional before use during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies and drug stores
Approval Status
DGDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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