Adlock
Generic Name
Amlodipine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adlock 10 mg tablet | ৳ 0.50 | ৳ 5.00 |
Description
Overview of the medicine
Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow channel blocker) that inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. It is used to treat hypertension and angina.
Uses & Indications
Dosage
Adults
Initial dose 5 mg once daily, maximum 10 mg once daily.
Elderly
Initial dose 2.5 mg once daily, then titrate.
Renal_impairment
No dosage adjustment usually required.
How to Take
May be taken with or without food.
Mechanism of Action
Amlodipine inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. This leads to peripheral vasodilation and reduced peripheral vascular resistance, thereby lowering blood pressure and reducing cardiac workload.
Pharmacokinetics
Onset
Gradual; takes several hours for full effect.
Excretion
Primarily excreted in urine (approximately 60% as metabolites, 10% as unchanged drug).
Half life
30-50 hours.
Absorption
Well absorbed orally; peak plasma concentrations 6-12 hours after administration. Absolute bioavailability is 64-90%.
Metabolism
Extensively metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to amlodipine or other dihydropyridine derivatives
- Severe hypotension
- Cardiogenic shock
- Significant aortic stenosis
Drug Interactions
Sildenafil
Concomitant use may lead to excessive hypotension.
Simvastatin
Limit simvastatin dose to 20 mg/day.
CYP3A4 inducers (e.g., rifampicin)
May decrease amlodipine exposure.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
May increase amlodipine exposure.
Storage
Store below 30°C in a dry place, away from light.
Overdose
Symptoms include excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia. Management involves symptomatic treatment and supportive measures.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Amlodipine is excreted in human milk; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to amlodipine or other dihydropyridine derivatives
- Severe hypotension
- Cardiogenic shock
- Significant aortic stenosis
Drug Interactions
Sildenafil
Concomitant use may lead to excessive hypotension.
Simvastatin
Limit simvastatin dose to 20 mg/day.
CYP3A4 inducers (e.g., rifampicin)
May decrease amlodipine exposure.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
May increase amlodipine exposure.
Storage
Store below 30°C in a dry place, away from light.
Overdose
Symptoms include excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia. Management involves symptomatic treatment and supportive measures.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Amlodipine is excreted in human milk; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Amlodipine has been extensively studied in various clinical trials for hypertension, angina, and cardiovascular risk reduction.
Lab Monitoring
- Generally not required for routine use. Monitor blood pressure.
Doctor Notes
- Educate patients on lifestyle modifications.
- Monitor blood pressure regularly.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine abruptly.
- Report any unusual side effects.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or somnolence. Patients should be cautious when driving or operating machinery.
Lifestyle Advice
- Adopt a healthy diet.
- Regular exercise.
- Reduce salt intake.
- Avoid smoking and excessive alcohol.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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