Adlock
Generic Name
Propranolol Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adlock 40 mg tablet | ৳ 1.70 | ৳ 17.00 |
Description
Overview of the medicine
Adlock-40 mg Tablet contains Propranolol Hydrochloride, a non-selective beta-adrenergic blocking agent. It is primarily used to treat high blood pressure, angina pectoris, cardiac arrhythmias, and migraine prophylaxis.
Uses & Indications
Dosage
Adults
For hypertension: Initially 40 mg twice daily, may be increased gradually at weekly intervals to 160-320 mg daily in divided doses. For angina: 40 mg two to three times daily, may be increased to 120-240 mg daily.
Elderly
Lower initial doses may be required, titrate carefully under medical supervision due to potential for increased sensitivity and reduced elimination.
Renal_impairment
No significant dosage adjustment needed for mild to moderate impairment. Use with caution in severe renal failure; monitor blood pressure and heart rate.
How to Take
Take Adlock-40 mg Tablet orally, preferably before meals or on an empty stomach. Swallow the tablet whole with water; do not crush or chew. Maintain consistent timing for doses.
Mechanism of Action
Propranolol blocks both beta-1 and beta-2 adrenergic receptors, which leads to a reduction in heart rate, cardiac output, and blood pressure. It also reduces sympathetic outflow from the central nervous system and inhibits renin release from the kidneys.
Pharmacokinetics
Onset
Oral: 30 minutes to 1 hour; Intravenous: immediate.
Excretion
Mainly through the kidneys (95% as metabolites, less than 1% as unchanged drug).
Half life
3-6 hours.
Absorption
Rapid and complete absorption from the gastrointestinal tract, but undergoes extensive first-pass metabolism, resulting in variable bioavailability (25-50%).
Metabolism
Extensively metabolized in the liver, primarily by glucuronidation, aromatic hydroxylation, and side-chain oxidation. Forms several active and inactive metabolites.
Side Effects
Contraindications
- Bronchial asthma or bronchospasm
- Cardiogenic shock
- Sinus bradycardia (<45-50 beats/min)
- Second or third-degree AV block
- Decompensated heart failure
- Severe peripheral arterial disease
Drug Interactions
Digoxin
Increased risk of bradycardia.
NSAIDs (e.g., Ibuprofen)
May reduce the antihypertensive effects of propranolol.
Insulin and Oral Hypoglycemics
Propranolol may mask symptoms of hypoglycemia (e.g., tremors, tachycardia) and can alter glucose levels. Dose adjustments may be necessary.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia, hypotension, and myocardial depression. Use with extreme caution.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, bronchospasm, acute heart failure, and hypoglycemia. Management is supportive, potentially including atropine for bradycardia, glucagon for cardiac effects, intravenous fluids, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C. Propranolol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; use with caution in nursing mothers and monitor the infant for signs of beta-blockade.
Side Effects
Contraindications
- Bronchial asthma or bronchospasm
- Cardiogenic shock
- Sinus bradycardia (<45-50 beats/min)
- Second or third-degree AV block
- Decompensated heart failure
- Severe peripheral arterial disease
Drug Interactions
Digoxin
Increased risk of bradycardia.
NSAIDs (e.g., Ibuprofen)
May reduce the antihypertensive effects of propranolol.
Insulin and Oral Hypoglycemics
Propranolol may mask symptoms of hypoglycemia (e.g., tremors, tachycardia) and can alter glucose levels. Dose adjustments may be necessary.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia, hypotension, and myocardial depression. Use with extreme caution.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, bronchospasm, acute heart failure, and hypoglycemia. Management is supportive, potentially including atropine for bradycardia, glucagon for cardiac effects, intravenous fluids, vasopressors for hypotension, and bronchodilators for bronchospasm.
Pregnancy & Lactation
Pregnancy Category C. Propranolol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; use with caution in nursing mothers and monitor the infant for signs of beta-blockade.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on the manufacturer.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Propranolol has been extensively studied in numerous clinical trials since its discovery, demonstrating proven efficacy in the management of hypertension, angina, arrhythmias, and migraine prophylaxis.
Lab Monitoring
- Blood pressure monitoring
- Heart rate monitoring
- ECG for arrhythmias (if indicated)
- Renal function (in patients with severe impairment)
- Blood glucose levels (in diabetic patients)
Doctor Notes
- Advise patients on the importance of gradual withdrawal to prevent rebound hypertension or worsening angina.
- Caution should be exercised in patients with underlying respiratory conditions (e.g., COPD), diabetes mellitus, and peripheral vascular disease.
- Monitor heart rate and blood pressure regularly. Avoid concurrent use with non-dihydropyridine calcium channel blockers like verapamil or diltiazem due to additive cardiodepressant effects.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor, as it can lead to serious heart problems.
- Report any difficulty breathing, severe dizziness, or slow heartbeat to your doctor immediately.
- Avoid driving or operating heavy machinery until you know how this medication affects you, as it may cause dizziness or fatigue.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Adlock-40 mg Tablet may cause dizziness, fatigue, or drowsiness, especially at the beginning of treatment. Patients should exercise caution when driving or operating machinery until they are certain the drug does not affect their ability.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Limit or avoid alcohol consumption.
- Quit smoking to improve cardiovascular health.
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