Admira-MR
Generic Name
Trimetazidine (Modified Release)
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| admira mr 30 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Trimetazidine is a metabolic agent used for the long-term treatment of angina pectoris. It helps improve myocardial glucose utilization, thereby reducing ischemic symptoms without significant hemodynamic changes.
Uses & Indications
Dosage
Adults
One 30 mg modified-release tablet once daily, taken with meals.
Elderly
No specific dose adjustment is required, but caution should be exercised due to potential renal impairment.
Renal_impairment
For patients with moderate renal impairment (creatinine clearance 30-60 mL/min), the recommended dose is one 30 mg tablet every other day. Contraindicated in severe renal impairment.
How to Take
Take the tablet orally with meals. Swallow the tablet whole with a glass of water; do not chew or crush it.
Mechanism of Action
Trimetazidine selectively inhibits 3-ketoacyl-CoA thiolase, an enzyme involved in fatty acid oxidation. This shifts myocardial energy metabolism towards glucose oxidation, which requires less oxygen per ATP molecule produced, thus improving myocardial efficiency under ischemic conditions.
Pharmacokinetics
Onset
Gradual, typically within 2 weeks of regular administration for full therapeutic effect.
Excretion
Primarily excreted in the urine, mainly as unchanged drug (about 80%).
Half life
Approximately 7 hours.
Absorption
Rapidly absorbed after oral administration. For modified-release formulation, peak plasma concentration is reached approximately 5 hours after dosing.
Metabolism
Undergoes minor hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Parkinson's disease, parkinsonian symptoms, restless leg syndrome, tremors, and other related movement disorders.
- Severe renal impairment (creatinine clearance < 30 mL/min).
Drug Interactions
No significant interactions
No clinically significant drug-drug interactions have been reported with Trimetazidine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited information on overdose. Management should be symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to lack of sufficient data. Should be used only if the potential benefit outweighs the potential risk, and under strict medical supervision.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Parkinson's disease, parkinsonian symptoms, restless leg syndrome, tremors, and other related movement disorders.
- Severe renal impairment (creatinine clearance < 30 mL/min).
Drug Interactions
No significant interactions
No clinically significant drug-drug interactions have been reported with Trimetazidine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited information on overdose. Management should be symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to lack of sufficient data. Should be used only if the potential benefit outweighs the potential risk, and under strict medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Trimetazidine has been extensively studied in clinical trials demonstrating its efficacy and safety in patients with ischemic heart disease, particularly for angina management.
Lab Monitoring
- Routine lab monitoring is not typically required.
Doctor Notes
- Trimetazidine is not a treatment for an acute angina attack.
- Contraindicated in Parkinson's disease and severe renal impairment. Consider dose reduction in moderate renal impairment.
- Monitor for extrapyramidal symptoms, especially in elderly patients.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not chew, crush, or break the tablet; swallow it whole.
- Inform your doctor if you experience any unusual side effects or worsening of symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Trimetazidine may cause dizziness or drowsiness. Patients should be cautioned about driving or operating machinery if they experience these symptoms.
Lifestyle Advice
- Maintain a healthy lifestyle, including a balanced diet and regular exercise.
- Avoid smoking and excessive alcohol consumption.
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