Medicine Information

Admira-MR

Name: Admira-MR
Brand: Admira-MR
Rating: 4.5 (117 reviews)

Tablet60 mgNon-steroidal anti-inflammatory drugs (NSAIDs)ATC: M01AH05

Generic Name

Etoricoxib

Manufacturer

Healthcare Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
admira mr 60 mg tablet	৳ 12.00	৳ 120.00

Description

Overview of the medicine

Admira-MR 60 mg Tablet contains Etoricoxib, a selective cyclooxygenase-2 (COX-2) inhibitor NSAID. It is used to relieve pain and reduce inflammation in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis, as well as for acute pain.

Uses & Indications

Symptomatic relief of osteoarthritis (OA)

Symptomatic relief of rheumatoid arthritis (RA)

Treatment of ankylosing spondylitis (AS)

Treatment of acute gouty arthritis

Relief of acute pain, including post-dental surgery pain

Dosage

Adults

Osteoarthritis: 30 mg or 60 mg once daily. Rheumatoid Arthritis/Ankylosing Spondylitis: 60 mg or 90 mg once daily. Acute Gouty Arthritis: 120 mg once daily for a maximum of 8 days. Acute Pain (including post-dental surgery): 60 mg or 90 mg once daily, for a maximum of 8 days (120 mg only for acute pain for max 8 days). The lowest effective dose for the shortest duration should be used.

Elderly

No specific dosage adjustment is required based on age; however, caution should be exercised in elderly patients due to increased risk of side effects.

Renal_impairment

Not recommended in severe renal impairment (CrCl <30 mL/min). For mild to moderate impairment, no dosage adjustment is generally needed, but caution is advised.

How to Take

Admira-MR tablets can be taken with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.

Mechanism of Action

Etoricoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, mediators of pain and inflammation. By inhibiting COX-2, Etoricoxib reduces prostaglandin production, thereby exerting its anti-inflammatory, analgesic, and antipyretic effects.

Pharmacokinetics

Onset

Within 1 hour for acute pain relief.

Excretion

Mainly excreted via urine (70%) and feces (20%) as metabolites, with less than 1% as unchanged drug.

Half life

Approximately 22 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are reached in approximately 1 hour (fasting). Bioavailability is about 100%.

Metabolism

Extensively metabolized by the liver, primarily via cytochrome P450 enzymes (CYP3A4) to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to etoricoxib or any excipient
Active peptic ulceration or gastrointestinal (GI) bleeding
Severe hepatic dysfunction
Severe renal impairment (CrCl <30 mL/min)
Patients with congestive heart failure (NYHA II-IV)
Patients with established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs

Drug Interactions

Lithium

May increase plasma lithium levels, leading to toxicity. Monitor lithium levels.

Warfarin

May increase INR and bleeding risk. Monitor INR closely.

Rifampicin

May decrease etoricoxib plasma concentrations.

Methotrexate

May increase methotrexate plasma levels and toxicity. Use with caution.

ACE Inhibitors/ARBs/Diuretics

May reduce the antihypertensive effect and increase the risk of renal impairment.

Oral Contraceptives/Hormone Replacement Therapy

May increase plasma concentrations of ethinyl estradiol, potentially increasing adverse event risk.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, symptoms may include gastrointestinal disturbances, renal impairment, and cardiovascular events. Management is symptomatic and supportive. There is no specific antidote for etoricoxib.

Pregnancy & Lactation

Not recommended during pregnancy, especially during the third trimester, due to potential fetal harm (e.g., premature closure of ductus arteriosus). Etoricoxib is excreted in breast milk; therefore, use is contraindicated during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets (1x10's blister pack)30 Tablets (3x10's blister pack)

Shelf Life

Typically 2-3 years from the date of manufacture, specific details on packaging.

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Off-patent (generic available)

Clinical Trials

Etoricoxib has undergone extensive clinical trials demonstrating its efficacy and safety in the management of various inflammatory and painful conditions, particularly for osteoarthritis, rheumatoid arthritis, and acute pain. Studies have evaluated its cardiovascular and gastrointestinal safety profiles compared to other NSAIDs.

Lab Monitoring

Blood pressure monitoring (especially in hypertensive patients)
Renal function tests (serum creatinine, BUN) in patients with pre-existing renal impairment or on long-term therapy
Liver function tests (ALT, AST) in patients with pre-existing hepatic impairment or signs of liver toxicity
Complete blood count (CBC) for long-term users to detect any hematological abnormalities

Doctor Notes

Prescribe the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
Carefully assess cardiovascular and gastrointestinal risk factors before prescribing and periodically during treatment.
Avoid use in patients with significant cardiovascular disease or high risk of GI complications.
Monitor blood pressure, renal function, and liver function, especially in patients on long-term therapy.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not exceed the recommended dose or duration of treatment.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Report any unusual symptoms or side effects to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Admira-MR may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.

Lifestyle Advice

Maintain a healthy lifestyle, including a balanced diet and regular exercise, if appropriate.
Limit alcohol consumption, as it may increase the risk of gastrointestinal bleeding associated with NSAID use.
Avoid smoking, as it is a risk factor for cardiovascular disease and GI ulceration.