Afalino
Generic Name
Afalino 125 mg tablet
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| afalino 125 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Afalino 125 mg Tablet is a broad-spectrum antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and urinary tract infections. It works by inhibiting bacterial growth.
Uses & Indications
Dosage
Adults
125 mg orally once daily for 7-10 days, depending on the infection.
Elderly
No specific dose adjustment required based on age, but monitor renal function.
Renal_impairment
Adjust dose for severe renal impairment (e.g., CrCl < 30 mL/min): 125 mg every 48 hours.
How to Take
Take orally with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Afalino works by interfering with bacterial DNA replication and repair mechanisms, leading to bacterial cell death. It specifically targets bacterial gyrase and topoisomerase IV enzymes.
Pharmacokinetics
Onset
Clinical effects typically observed within 24-48 hours of first dose.
Excretion
Mainly excreted through urine as unchanged drug and metabolites.
Half life
Approximately 6-8 hours, allowing for once or twice daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via CYP450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Afalino or any components of the tablet
- History of tendinitis or tendon rupture associated with fluoroquinolones
- Myasthenia gravis
Drug Interactions
Warfarin
May increase the anticoagulant effect of warfarin. Monitor INR closely.
Theophylline
May increase theophylline levels and risk of toxicity. Monitor theophylline levels.
Antacids containing aluminum or magnesium
May decrease absorption of Afalino. Administer Afalino 2 hours before or 6 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, dizziness, confusion, and seizures. Treatment is symptomatic and supportive; hemodialysis is not effective.
Pregnancy & Lactation
Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; avoid use during lactation or monitor infant for adverse effects.
Side Effects
Contraindications
- Hypersensitivity to Afalino or any components of the tablet
- History of tendinitis or tendon rupture associated with fluoroquinolones
- Myasthenia gravis
Drug Interactions
Warfarin
May increase the anticoagulant effect of warfarin. Monitor INR closely.
Theophylline
May increase theophylline levels and risk of toxicity. Monitor theophylline levels.
Antacids containing aluminum or magnesium
May decrease absorption of Afalino. Administer Afalino 2 hours before or 6 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, dizziness, confusion, and seizures. Treatment is symptomatic and supportive; hemodialysis is not effective.
Pregnancy & Lactation
Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; avoid use during lactation or monitor infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent protected
Clinical Trials
Phase III clinical trials demonstrated significant efficacy and acceptable safety profile in target indications. Further post-marketing surveillance is ongoing.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Liver function tests (baseline and if symptoms occur)
- INR (if co-administered with warfarin)
Doctor Notes
- Counsel patients on completing the full course to prevent resistance.
- Be vigilant for signs of tendinopathy, especially in elderly patients or those on corticosteroids.
- Advise patients to report any unusual neurological symptoms immediately.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Do not share this medication with others.
- Stay hydrated by drinking plenty of fluids.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. Exercise caution when driving or operating machinery until you know how Afalino affects you.
Lifestyle Advice
- Avoid excessive sunlight exposure as Afalino may increase photosensitivity.
- Limit alcohol consumption during treatment.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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