Afalino
Generic Name
Afalino-50-mg-tablet
Manufacturer
Globex Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| afalino 50 mg tablet | ৳ 65.00 | ৳ 650.00 |
Description
Overview of the medicine
Afalino 50 mg Tablet is a beta-blocker used to treat high blood pressure, angina, and certain heart rhythm disorders. It works by blocking the action of certain natural chemicals in your body, like epinephrine, on the heart and blood vessels.
Uses & Indications
Dosage
Adults
Initially 50 mg once daily, increased to 100-200 mg daily if needed, depending on response. Max 400 mg/day.
Elderly
Lower initial doses (e.g., 25 mg once daily) may be appropriate, with careful titration.
Renal_impairment
Dosage adjustment may be necessary in severe renal impairment (CrCl < 30 mL/min). Consult physician.
How to Take
Take Afalino 50 mg Tablet orally with or without food, usually once daily. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Afalino is a non-selective beta-adrenergic receptor antagonist. It blocks both beta-1 and beta-2 adrenergic receptors, leading to decreased heart rate, reduced myocardial contractility, and lower blood pressure. It also inhibits renin release.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Excreted primarily via urine (both unchanged drug and metabolites).
Half life
3-6 hours
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract; however, it undergoes significant first-pass metabolism, resulting in bioavailability of about 30-50%.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 enzymes (e.g., CYP2D6).
Side Effects
Contraindications
- Severe bradycardia (heart rate < 50 bpm)
- Cardiogenic shock
- Decompensated heart failure
- Severe asthma or COPD
Drug Interactions
Insulin and oral antidiabetics
May mask symptoms of hypoglycemia.
NSAIDs (Nonsteroidal anti-inflammatory drugs)
May reduce the antihypertensive effect of Afalino.
Calcium channel blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, bronchospasm, and acute heart failure. Treatment is supportive, involving atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm. Hemodialysis may be considered.
Pregnancy & Lactation
Use during pregnancy is generally not recommended unless clearly necessary. Consult your doctor. Afalino is excreted in breast milk; avoid during lactation or use with caution under medical supervision.
Side Effects
Contraindications
- Severe bradycardia (heart rate < 50 bpm)
- Cardiogenic shock
- Decompensated heart failure
- Severe asthma or COPD
Drug Interactions
Insulin and oral antidiabetics
May mask symptoms of hypoglycemia.
NSAIDs (Nonsteroidal anti-inflammatory drugs)
May reduce the antihypertensive effect of Afalino.
Calcium channel blockers (e.g., verapamil, diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, bronchospasm, and acute heart failure. Treatment is supportive, involving atropine for bradycardia, vasopressors for hypotension, and bronchodilators for bronchospasm. Hemodialysis may be considered.
Pregnancy & Lactation
Use during pregnancy is generally not recommended unless clearly necessary. Consult your doctor. Afalino is excreted in breast milk; avoid during lactation or use with caution under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities in several countries
Patent Status
Patent protected until 2035
Clinical Trials
Phase III clinical trials demonstrated significant reduction in blood pressure compared to placebo. Ongoing post-marketing surveillance for long-term safety and efficacy.
Lab Monitoring
- Blood pressure monitoring
- Heart rate monitoring
- Renal function tests (for patients with kidney impairment)
- Blood glucose (for diabetic patients)
Doctor Notes
- Advise patients to report any unusual side effects, especially new or worsening depression.
- Counsel patients on the importance of adherence and not discontinuing abruptly.
- Consider the patient's full medical history, especially respiratory conditions, before prescribing.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Monitor your blood pressure regularly as advised by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment. Avoid driving or operating heavy machinery until you know how Afalino affects you.
Lifestyle Advice
- Adopt a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as approved by your doctor.
- Limit alcohol consumption.
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Global Brand Names
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