Airway
Generic Name
Montelukast
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| airway 10 mg tablet | ৳ 17.00 | ৳ 170.00 |
Description
Overview of the medicine
Airway 10 mg tablet contains Montelukast, a leukotriene receptor antagonist used for the treatment of asthma and allergic rhinitis. It helps to reduce inflammation and relax the airways.
Uses & Indications
Dosage
Adults
For asthma and allergic rhinitis: 10 mg once daily, in the evening. For EIB: 10 mg at least 2 hours before exercise, not to be repeated within 24 hours.
Elderly
No dosage adjustment is generally required. However, use with caution due to potential age-related changes in pharmacokinetics.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Take orally, once daily in the evening, with or without food. For exercise-induced bronchoconstriction, take at least 2 hours before exercise and do not take an additional dose for other indications on the same day.
Mechanism of Action
Montelukast selectively blocks the cysteinyl leukotriene 1 (CysLT1) receptor, preventing the bronchoconstriction and inflammatory effects of leukotrienes. Leukotrienes are potent inflammatory mediators involved in asthma and allergic rhinitis.
Pharmacokinetics
Onset
Within 1 day for asthma symptoms. Full therapeutic effect may take several days.
Excretion
Primarily excreted in the bile and feces (approximately 86%); negligible renal excretion (less than 0.2%).
Half life
Approximately 2.7 to 5.5 hours in adults.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration (Tmax) is reached in 2-4 hours for adults.
Metabolism
Extensively metabolized by cytochrome P450 enzymes (CYP3A4, CYP2C9, and CYP2A6) in the liver.
Side Effects
Contraindications
- Hypersensitivity to montelukast or any component of the formulation.
- Acute asthma attacks (not indicated for reversal of bronchospasm in acute asthma).
Drug Interactions
Rifampin
May decrease montelukast plasma concentrations by approximately 40%, but no dose adjustment is routinely recommended.
Phenobarbital
May decrease montelukast plasma concentrations by approximately 40%.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive; no specific antidote is known. Consult a healthcare provider immediately.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Montelukast is excreted in breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to montelukast or any component of the formulation.
- Acute asthma attacks (not indicated for reversal of bronchospasm in acute asthma).
Drug Interactions
Rifampin
May decrease montelukast plasma concentrations by approximately 40%, but no dose adjustment is routinely recommended.
Phenobarbital
May decrease montelukast plasma concentrations by approximately 40%.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive; no specific antidote is known. Consult a healthcare provider immediately.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Montelukast is excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of montelukast in the prophylaxis and chronic treatment of asthma and for the relief of allergic rhinitis symptoms across various age groups. Studies have also confirmed its role in preventing exercise-induced bronchoconstriction.
Lab Monitoring
- No specific routine lab monitoring is required for montelukast. Liver function tests may be considered in patients with pre-existing liver impairment.
Doctor Notes
- Advise patients that Airway 10 mg is a controller medication for long-term management, not a rescue medication for acute exacerbations.
- Counsel patients on the potential for neuropsychiatric events and instruct them to report any behavioral or mood changes immediately.
- Emphasize adherence to the daily dosing regimen (preferably in the evening) for optimal therapeutic benefits and to ensure continuous asthma control or rhinitis symptom relief.
Patient Guidelines
- Do not use Airway 10 mg tablet for sudden, acute asthma attacks. Always carry your rescue inhaler for such situations.
- Continue taking the medicine regularly, even if you feel well, as it is a long-term control medication.
- Inform your doctor immediately if you experience any psychiatric symptoms (e.g., agitation, depression, suicidal thoughts, nightmares).
- Do not stop other asthma medications unless specifically advised by your doctor.
Missed Dose Advice
If a dose is missed, take the next dose at the regular time. Do not double the dose to compensate for a missed dose.
Driving Precautions
Airway 10 mg tablet may cause dizziness or drowsiness in some individuals. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Identify and avoid asthma and allergy triggers (e.g., pollen, dust mites, pet dander, mold).
- Maintain a healthy lifestyle, including regular exercise (if permitted by your condition) and a balanced diet.
- Consider using an air purifier at home if allergic to airborne particles.
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