Airway
Generic Name
Montelukast
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| airway 5 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Airway 5 mg Tablet is used to prevent and treat asthma and to relieve symptoms of seasonal and perennial allergic rhinitis. It contains Montelukast as the active ingredient.
Uses & Indications
Dosage
Adults
Not typically used for adults; adult dose is usually 10 mg.
Elderly
No dosage adjustment necessary for elderly patients.
Children
For children 6-14 years: 5 mg once daily in the evening. For children 2-5 years: 4 mg (chewable tablet).
Renal_impairment
No dosage adjustment necessary for patients with renal impairment.
How to Take
Take orally once daily in the evening, with or without food. For asthma, take in the evening. For allergic rhinitis, the time of administration may be individualized. For exercise-induced bronchoconstriction, take at least 2 hours before exercise.
Mechanism of Action
Montelukast selectively blocks the action of leukotrienes, which are natural substances in the body that cause inflammation, narrowing of airways, and mucus production. By blocking these effects, it helps to improve asthma symptoms and allergic rhinitis.
Pharmacokinetics
Onset
Within 1 day for asthma/allergic rhinitis relief.
Excretion
Primarily excreted in faeces (approximately 86%) and to a lesser extent in urine (less than 0.2%) via bile.
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly absorbed from the GI tract after oral administration. Peak plasma concentration achieved in 2-4 hours.
Metabolism
Extensively metabolized in the liver by CYP2C8, CYP3A4, and CYP2C9 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the tablet
Drug Interactions
Rifampin
May decrease the plasma concentration of Montelukast.
Phenobarbital
May decrease the plasma concentration of Montelukast.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use in pregnancy only if clearly needed. Excretion into breast milk is unknown, use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the tablet
Drug Interactions
Rifampin
May decrease the plasma concentration of Montelukast.
Phenobarbital
May decrease the plasma concentration of Montelukast.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use in pregnancy only if clearly needed. Excretion into breast milk is unknown, use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated Montelukast's efficacy and safety in preventing asthma attacks, improving lung function, and reducing symptoms of allergic rhinitis in patients of various age groups.
Lab Monitoring
- No routine laboratory monitoring required. Liver function tests may be considered in patients with pre-existing liver impairment.
Doctor Notes
- Emphasize to patients that this is a prophylactic agent, not for acute relief.
- Educate on potential neuropsychiatric side effects and advise immediate reporting of any such symptoms.
- Consider alternative treatments if neuropsychiatric symptoms develop or worsen.
Patient Guidelines
- Do not use to treat acute asthma attacks. Always carry your rescue inhaler.
- Take as prescribed, usually once daily in the evening.
- Inform your doctor about any unusual mood or behavior changes.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness in some individuals; caution is advised when driving or operating machinery.
Lifestyle Advice
- Avoid known asthma triggers.
- Maintain a healthy lifestyle with regular exercise (if appropriate) and a balanced diet.
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Global Brand Names
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