Alatrol
Generic Name
Cetirizine Hydrochloride 5 mg/5 ml syrup
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alatrol 5 mg syrup | ৳ 35.00 | N/A |
Description
Overview of the medicine
Alatrol 5 mg/5 ml syrup contains Cetirizine, an antihistamine used to relieve symptoms of allergies such as sneezing, runny nose, itching, watery eyes, and hives.
Uses & Indications
Dosage
Adults
10 ml (5 mg/5 ml syrup) once daily or 5 ml (5 mg/5 ml syrup) twice daily.
Elderly
5 ml (5 mg/5 ml syrup) once daily. Dosage adjustment may be needed due to reduced renal function.
Renal_impairment
Moderate renal impairment (creatinine clearance 31-50 ml/min): 5 ml (5 mg/5 ml syrup) once daily. Severe renal impairment (creatinine clearance < 30 ml/min): 5 ml (5 mg/5 ml syrup) every other day.
How to Take
Alatrol syrup should be taken orally, with or without food. Use a measuring spoon or cup to ensure accurate dosing.
Mechanism of Action
Cetirizine works by blocking the action of histamine, a natural substance in the body that causes allergic symptoms. It selectively inhibits peripheral H1-receptors.
Pharmacokinetics
Onset
Onset of action is usually within 20-60 minutes.
Excretion
Primarily excreted in the urine, largely as unchanged drug.
Half life
Plasma elimination half-life is approximately 8-11 hours in adults, shorter in children (6 hours for 6-12 years, 5 hours for 2-6 years).
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 1 hour.
Metabolism
Minimal hepatic metabolism; approximately two-thirds of the dose is excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Severe renal impairment (creatinine clearance < 10 ml/min).
Drug Interactions
CNS Depressants (e.g., alcohol, sedatives)
Concurrent use may increase central nervous system depression, potentially enhancing drowsiness.
Storage
Store below 30°C. Protect from light and moisture. Keep out of the reach of children.
Overdose
Symptoms of overdose may include drowsiness, agitation, tachycardia, tremor, and headache. In children, agitation may be more prominent. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of fetal harm, but adequate studies in pregnant women are lacking. It is excreted in breast milk, so use with caution during lactation. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Severe renal impairment (creatinine clearance < 10 ml/min).
Drug Interactions
CNS Depressants (e.g., alcohol, sedatives)
Concurrent use may increase central nervous system depression, potentially enhancing drowsiness.
Storage
Store below 30°C. Protect from light and moisture. Keep out of the reach of children.
Overdose
Symptoms of overdose may include drowsiness, agitation, tachycardia, tremor, and headache. In children, agitation may be more prominent. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of fetal harm, but adequate studies in pregnant women are lacking. It is excreted in breast milk, so use with caution during lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific expiry date mentioned on the packaging.
Availability
Pharmacies, Drugstores
Approval Status
Globally approved and widely available
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cetirizine has undergone extensive clinical trials demonstrating its efficacy and safety for allergic conditions. It has been widely studied in both adult and pediatric populations.
Lab Monitoring
- Routine lab monitoring is not typically required for Cetirizine therapy.
Doctor Notes
- Advise patients on appropriate dosing for age and renal function, especially in children and elderly.
- Counsel on potential drowsiness and its implications for driving/operating machinery.
- Emphasize identifying and avoiding allergens for better allergy management.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor or as indicated on the label.
- Do not exceed the recommended dose.
- Inform your doctor or pharmacist about all other medications you are taking.
- Avoid alcohol while taking this medicine, as it may increase drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.
Driving Precautions
This medicine may cause drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain good hygiene to reduce exposure to allergens.
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