Alice
Generic Name
Alice (hypothetical API) 6 mg
Manufacturer
PharmaCo Global
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| alice 6 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Alice 6 mg Tablet is an antidepressant medication used to treat various mood disorders, including major depressive disorder and generalized anxiety disorder. It helps restore the balance of certain natural substances (neurotransmitters) in the brain.
Uses & Indications
Dosage
Adults
Initially 6 mg once daily, may be increased to 12 mg after 1 week based on response. Max 18 mg/day.
Elderly
Start with 3 mg once daily, gradually increase if necessary.
Renal_impairment
No dose adjustment needed for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take orally with or without food, usually once daily in the morning.
Mechanism of Action
Alice selectively inhibits the reuptake of serotonin (5-HT) into presynaptic neurons, thereby increasing the concentration of serotonin in the synaptic cleft and enhancing serotonergic neurotransmission.
Pharmacokinetics
Onset
Therapeutic effects may begin within 1-2 weeks, full effect in 4-6 weeks.
Excretion
Primarily excreted in urine as metabolites, with a small amount in feces.
Half life
Approximately 20-24 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally, peak plasma concentrations reached in 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP450 enzymes (e.g., CYP2D6, CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Alice or any excipients
- Concomitant use with MAOIs
- Severe hepatic impairment
Drug Interactions
MAOIs
Risk of serotonin syndrome. Should not be used within 14 days of discontinuing an MAOI or starting an MAOI.
NSAIDs
Increased risk of gastrointestinal bleeding when used concomitantly.
Warfarin
May increase the risk of bleeding due to effects on platelet aggregation.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, tachycardia, tremor, and seizures. Treatment is symptomatic and supportive; consider activated charcoal and gastric lavage.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, use with caution or consider alternatives during lactation.
Side Effects
Contraindications
- Hypersensitivity to Alice or any excipients
- Concomitant use with MAOIs
- Severe hepatic impairment
Drug Interactions
MAOIs
Risk of serotonin syndrome. Should not be used within 14 days of discontinuing an MAOI or starting an MAOI.
NSAIDs
Increased risk of gastrointestinal bleeding when used concomitantly.
Warfarin
May increase the risk of bleeding due to effects on platelet aggregation.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, tachycardia, tremor, and seizures. Treatment is symptomatic and supportive; consider activated charcoal and gastric lavage.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk, use with caution or consider alternatives during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Patent expired
Clinical Trials
Phase III trials demonstrated significant efficacy in reducing symptoms of depression and anxiety compared to placebo. Ongoing long-term safety studies.
Lab Monitoring
- Liver function tests (baseline and periodic)
- Electrolytes (especially sodium if hyponatremia suspected)
Doctor Notes
- Advise patients about potential delay in therapeutic onset.
- Monitor for signs of serotonin syndrome, especially when co-administered with other serotonergic agents.
- Regular follow-up for suicidality in young patients is crucial.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor.
- It may take several weeks to feel the full benefits.
- Report any worsening of depression or suicidal thoughts immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Engage in regular exercise.
- Maintain a balanced diet and adequate sleep.
- Avoid or limit alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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