Alistin-EF
Generic Name
Fexofenadine Hydrochloride + Pseudoephedrine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Alistin-EF is a combination medicine containing Fexofenadine (an antihistamine) and Pseudoephedrine (a decongestant). It is used to relieve symptoms associated with seasonal allergic rhinitis, such as sneezing, runny nose, itchy throat, itchy watery eyes, and nasal congestion.
Uses & Indications
Dosage
Adults
One tablet (Fexofenadine 60 mg/Pseudoephedrine 120 mg) orally twice daily, or as directed by the physician. For extended-release formulations, typically one tablet once daily.
Elderly
No specific dose adjustment is usually necessary for the elderly with normal renal function, but caution is advised. Consult a physician.
Renal_impairment
Initial dose should be reduced (e.g., one tablet once daily for Fexofenadine/Pseudoephedrine 60 mg/120 mg formulation) in patients with impaired renal function (creatinine clearance < 80 mL/min). Consult a physician.
How to Take
Take orally with a glass of water, with or without food. Do not crush, chew, or break the extended-release tablet.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist, blocking the effects of histamine and reducing allergic symptoms. Pseudoephedrine is a sympathomimetic amine that acts directly and indirectly on adrenergic receptors. It causes vasoconstriction of blood vessels in the nasal mucosa, leading to decongestion.
Pharmacokinetics
Onset
Within 1 hour for symptom relief.
Excretion
Fexofenadine is primarily excreted unchanged in the feces and urine. Pseudoephedrine is primarily excreted unchanged in the urine; excretion is pH-dependent.
Half life
Fexofenadine: Approximately 14 hours. Pseudoephedrine: Approximately 9-16 hours.
Absorption
Fexofenadine is rapidly absorbed, with peak plasma concentrations occurring within 1-3 hours. Pseudoephedrine is also well absorbed from the gastrointestinal tract.
Metabolism
Fexofenadine undergoes negligible metabolism. Pseudoephedrine undergoes partial metabolism in the liver.
Side Effects
Contraindications
- •Hypersensitivity to fexofenadine, pseudoephedrine, or any component of the formulation
- •Severe hypertension
- •Severe coronary artery disease
- •Patients taking monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy
- •Narrow-angle glaucoma
- •Urinary retention
Drug Interactions
Digoxin
Increased risk of arrhythmia.
Erythromycin or Ketoconazole
May increase fexofenadine plasma concentrations.
Monoamine Oxidase Inhibitors (MAOIs)
Concurrent use or use within 14 days of MAOI discontinuation can lead to hypertensive crisis.
Antacids containing aluminum or magnesium
May decrease the absorption of fexofenadine. Separate administration by at least 2 hours.
Beta-blockers and other antihypertensive agents
Pseudoephedrine may reduce the antihypertensive effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dry mouth, dizziness, nervousness, blurred vision, headache, stomach upset, and increased heart rate. In case of overdose, seek immediate medical attention. Treatment is primarily symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C for pseudoephedrine and Category B for fexofenadine. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pseudoephedrine and fexofenadine are excreted in breast milk; therefore, caution should be exercised when Alistin-EF is administered to a nursing woman. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
DGDA Approved (Bangladesh)
Patent Status
Generic available, original patent expired
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Global Brand Names
International brand names for this medicine
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