Amboxol
Generic Name
Ambroxol hydrochloride
Manufacturer
Multiple generic manufacturers
Country
Global (manufactured worldwide)
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amboxol 15 mg syrup | ৳ 42.00 | N/A |
Description
Overview of the medicine
Ambroxol is a mucolytic agent used to treat respiratory diseases associated with viscous mucus. It helps to thin and loosen phlegm, making it easier to cough up.
Uses & Indications
Dosage
Adults
10 ml (30 mg) 2-3 times daily, or 5 ml (15 mg) 3 times daily. Initial dosage can be higher under medical supervision.
Elderly
Same as adult dosage, no specific dose adjustment required unless severe renal or hepatic impairment.
Renal_impairment
Dose reduction or increased dosing interval may be necessary in severe renal impairment (eGFR < 30 mL/min). Consult a physician.
How to Take
Administer orally, with or without food. Use the provided measuring cup or spoon for accurate dosing.
Mechanism of Action
Ambroxol works by stimulating serous mucus secretion and by depolymerizing mucopolysaccharides, thereby reducing mucus viscosity. It also activates mucociliary clearance.
Pharmacokinetics
Onset
Mucolytic effect starts approximately 30 minutes after oral administration.
Excretion
Mainly excreted renally (about 90%) as metabolites, with a small portion as unchanged drug.
Half life
Approximately 7-12 hours for the parent drug.
Absorption
Rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are reached after 1-2.5 hours.
Metabolism
Undergoes extensive first-pass metabolism in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ambroxol or any excipients.
- Patients with known hereditary problems of fructose intolerance (due to sorbitol content in some formulations).
- Caution in patients with peptic ulcer disease.
Drug Interactions
Antibiotics (Amoxicillin, Cefuroxime, Erythromycin)
Ambroxol may increase the penetration of antibiotics into bronchial secretions, potentially enhancing their efficacy.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include nausea, vomiting, diarrhea, and dyspepsia. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy, especially in the first trimester, should be avoided unless strictly indicated. Limited data exist for lactation; use with caution and only if potential benefits outweigh risks. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Ambroxol or any excipients.
- Patients with known hereditary problems of fructose intolerance (due to sorbitol content in some formulations).
- Caution in patients with peptic ulcer disease.
Drug Interactions
Antibiotics (Amoxicillin, Cefuroxime, Erythromycin)
Ambroxol may increase the penetration of antibiotics into bronchial secretions, potentially enhancing their efficacy.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include nausea, vomiting, diarrhea, and dyspepsia. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy, especially in the first trimester, should be avoided unless strictly indicated. Limited data exist for lactation; use with caution and only if potential benefits outweigh risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture when stored properly. Check packaging for specific expiry date.
Availability
Available in pharmacies and hospitals worldwide
Approval Status
Approved (Globally, including DGDA, FDA)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Ambroxol has been widely studied in numerous clinical trials for its efficacy and safety in various respiratory conditions over several decades.
Lab Monitoring
- No specific routine lab monitoring is required for ambroxol therapy.
- Liver and kidney function tests may be considered in patients with pre-existing impairment.
Doctor Notes
- Advise patients on the importance of hydration to enhance mucolytic effect.
- Counsel on recognizing and immediately reporting signs of severe skin reactions.
- Consider dose adjustment in patients with severe hepatic or renal impairment.
- It can be combined with antibiotics to improve their penetration into bronchial secretions.
Patient Guidelines
- Do not exceed the recommended dose.
- Ensure adequate hydration while on therapy.
- If symptoms persist or worsen, consult your doctor.
- Report any severe skin reactions immediately to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Ambroxol is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, patients should avoid driving.
Lifestyle Advice
- Maintain good hydration.
- Avoid smoking, as it irritates the respiratory tract.
- Avoid exposure to environmental pollutants and allergens.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Amboxol Brand
Other medicines available under the same brand name
