Amidol
Generic Name
Paracetamol (Acetaminophen) Injection
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amidol 370 mg injection | ৳ 1,318.00 | N/A |
Description
Overview of the medicine
Amidol 370 mg Injection is an intravenous formulation of paracetamol, used for the short-term treatment of moderate pain, especially post-operative pain, and for the short-term treatment of fever, when administration by the intravenous route is clinically justified.
Uses & Indications
Dosage
Adults
370 mg to 740 mg (1-2 vials) administered as an intravenous infusion over 15 minutes, up to 4 times daily. Maximum daily dose is 4000 mg (approximately 10 vials), however, for Amidol 370 mg, usually not exceeding 2960 mg (8 vials) per day, to avoid excessive fluid volume.
Elderly
No specific dose adjustment is required in elderly patients, unless there is significant renal or hepatic impairment. Close monitoring is advised.
Renal_impairment
In severe renal impairment (creatinine clearance < 30 mL/min), the interval between doses should be extended to at least 6 hours, and maximum daily dose may need reduction. Consult a physician for specific guidance.
How to Take
Amidol 370 mg Injection is for intravenous use only. It should be administered as an intravenous infusion over 15 minutes. It should not be administered as a rapid bolus injection.
Mechanism of Action
Paracetamol's mechanism of action is believed to involve inhibition of prostaglandin synthesis, primarily in the central nervous system (CNS), and modulation of the endogenous cannabinoid system. It exerts its analgesic and antipyretic effects by acting centrally, likely through inhibition of COX-3 or other central mechanisms, leading to reduced pain perception and thermoregulation.
Pharmacokinetics
Onset
Analgesia and antipyresis typically begin within 5-10 minutes of administration.
Excretion
Mainly excreted in urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Plasma elimination half-life is approximately 2-3 hours in adults, slightly shorter in children and slightly longer in neonates and patients with hepatic impairment.
Absorption
Rapid and complete absorption after intravenous administration, reaching peak plasma concentrations within 5-10 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small portion is metabolized by cytochrome P450 (CYP2E1) to a highly reactive intermediate (NAPQI), which is rapidly detoxified by conjugation with glutathione.
Side Effects
Contraindications
- •Hypersensitivity to paracetamol or to propacetamol (a prodrug of paracetamol) or to any of the excipients.
- •Severe hepatocellular insufficiency or active liver disease.
Drug Interactions
Probenecid
Reduces paracetamol clearance by almost 50%, requiring a dose reduction.
Cholestyramine
Reduces the absorption of paracetamol, if administered orally; not relevant for injection.
Warfarin and other coumarins
Increased anticoagulant effect, leading to an increased risk of bleeding. Regular monitoring of INR is advised.
Hepatotoxic drugs (e.g., phenobarbital, phenytoin, carbamazepine)
Increased risk of paracetamol hepatotoxicity due to enhanced formation of the toxic metabolite (NAPQI).
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Symptoms of paracetamol overdose include nausea, vomiting, anorexia, pallor, and abdominal pain, usually appearing within 24 hours. Hepatic necrosis can develop, which may lead to complete and irreversible liver failure. Antidote is N-acetylcysteine (NAC), which should be administered as early as possible. Medical attention is crucial.
Pregnancy & Lactation
Amidol 370 mg Injection can be used during pregnancy if clinically needed, but at the lowest effective dose for the shortest possible duration. It is excreted into breast milk in small amounts; generally considered compatible with breastfeeding when used at therapeutic doses. Consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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