Take Amifen 500 mg Tablet orally, preferably with food or milk to minimize gastrointestinal upset. Do not crush or chew the tablet.

Mefenamic Acid works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain, inflammation, and fever. It achieves this by reversibly inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes.

• •Hypersensitivity to mefenamic acid, aspirin, or other NSAIDs.
• •Patients with active peptic ulceration or chronic inflammatory bowel disease.
• •Patients with a history of aspirin-sensitive asthma, urticaria, or other allergic reactions to NSAIDs.
• •Severe renal or hepatic impairment.
• •Last trimester of pregnancy (due to risk of premature closure of fetal ductus arteriosus).

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and occasionally diarrhea. More severe cases may lead to acute renal failure, coma, or convulsions. Management involves symptomatic and supportive treatment. Gastric lavage, activated charcoal, and ensuring adequate hydration may be helpful. Urine alkalinization may enhance excretion.

Pregnancy Category C (first two trimesters), D (third trimester). Should be avoided in the third trimester due to potential adverse effects on the fetal cardiovascular system. Avoid in nursing mothers as Mefenamic Acid is excreted in breast milk.