Amotid-CL
Generic Name
Amoxicillin and Clavulanate Potassium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amotid cl 125 mg suspension | ৳ 200.00 | N/A |
Description
Overview of the medicine
Amotid-CL 125 mg Suspension is an antibiotic medication containing Amoxicillin and Clavulanate Potassium, used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Generally not prescribed for adults in this specific strength and formulation; adult formulations are typically higher strength tablets or capsules.
Elderly
Dosage should be adjusted based on renal function and overall health status. Consult a physician.
Renal_impairment
For creatinine clearance >30 mL/min, no dose adjustment. For 10-30 mL/min, 125 mg (amoxicillin) every 12 hours. For <10 mL/min, 125 mg (amoxicillin) every 24 hours.
How to Take
Shake well before use. Administer orally with food to minimize gastrointestinal discomfort. Use a measuring spoon/cup provided.
Mechanism of Action
Amoxicillin is a penicillin antibiotic that inhibits bacterial cell wall synthesis. Clavulanic acid is a beta-lactamase inhibitor that prevents bacterial enzymes from inactivating amoxicillin, thus extending its antibacterial spectrum.
Pharmacokinetics
Onset
Peak plasma concentration within 1-2 hours.
Excretion
Primarily renal (urine).
Half life
Amoxicillin: 1.3 hours; Clavulanate: 1 hour.
Absorption
Well absorbed orally, food can reduce absorption of clavulanate but not amoxicillin.
Metabolism
Amoxicillin is partially metabolized; Clavulanate is extensively metabolized.
Side Effects
Contraindications
- •History of hypersensitivity to penicillin or clavulanate
- •History of cholestatic jaundice/hepatic dysfunction associated with amoxicillin/clavulanate
- •Infectious mononucleosis
Drug Interactions
Probenecid
Increases and prolongs amoxicillin blood levels.
Methotrexate
May increase methotrexate toxicity.
Oral Contraceptives
May decrease efficacy of oral contraceptives.
Anticoagulants (e.g., Warfarin)
May prolong prothrombin time; monitor INR.
Storage
Store dry powder below 25°C in a dry place, away from direct light. Reconstituted suspension should be stored in a refrigerator (2°C-8°C) and discarded after 7-10 days. Do not freeze.
Overdose
Symptoms may include gastrointestinal upset and fluid/electrolyte imbalance. Treatment involves symptomatic and supportive measures, and hemodialysis can remove amoxicillin/clavulanate from circulation.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy and lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years for dry powder. 7-10 days after reconstitution when refrigerated.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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