Adults

Most infections: 250 mg twice daily for 7-10 days. For more severe infections or certain UTIs: 500 mg twice daily. For pharyngitis/tonsillitis: 250 mg twice daily.

Elderly

No specific dosage adjustment required based on age, but renal function should be considered.

Renal_impairment

Creatinine clearance 10-29 mL/min: 250 mg or 500 mg once daily. Creatinine clearance <10 mL/min: 250 mg or 500 mg every 48 hours.

Onset

Peak plasma concentrations achieved within 2-3 hours after oral administration.

Excretion

Primarily excreted unchanged by the kidneys, through glomerular filtration and tubular secretion.

Half life

Approximately 1.2 to 1.5 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract and rapidly hydrolyzed by esterases to cefuroxime. Oral bioavailability is approximately 37-52% when taken with food.

Metabolism

Not significantly metabolized in the liver; largely excreted unchanged.

Antacids

Drugs that reduce gastric acidity may result in a lower bioavailability of cefuroxime axetil. Concurrent administration should be avoided.

Probenecid

Concomitant administration with probenecid increases the area under the serum concentration versus time curve by 50%.

Oral Contraceptives

Cefuroxime may decrease the efficacy of oral contraceptives. Advise women to use an alternative or additional method of contraception.