Amzith
Generic Name
Azithromycin 200 mg Suspension
Manufacturer
ACME Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| amzith 200 mg suspension | ৳ 130.00 | N/A |
Description
Overview of the medicine
Amzith 200 mg Suspension is a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted infections.
Uses & Indications
Dosage
Adults
Not typically used for adults in suspension form; adults usually take tablets/capsules.
Elderly
No specific dosage adjustment needed for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment necessary for mild to moderate renal impairment (creatinine clearance > 10 mL/min). Exercise caution in severe impairment.
How to Take
Administer orally once daily, with or without food. Measure the dose accurately using the provided measuring device. Shake well before use.
Mechanism of Action
Azithromycin works by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit of susceptible microorganisms, thereby interfering with the translation of mRNA and ultimately inhibiting bacterial growth.
Pharmacokinetics
Onset
Within 2-3 hours (clinical effect may take longer to manifest)
Excretion
Mainly excreted unchanged in bile (approximately 50%), with a smaller amount (about 6%) excreted in urine.
Half life
Approximately 2-4 days (due to extensive tissue uptake and slow release)
Absorption
Rapidly absorbed from the gastrointestinal tract; however, bioavailability is approximately 37%. Peak plasma concentrations occur 2-3 hours after administration. Food can reduce peak concentrations but total absorption remains similar.
Metabolism
Primarily hepatic, undergoes N-demethylation; however, a significant portion is excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
May increase serum digoxin levels; monitor digoxin levels.
Antacids
Reduced peak plasma levels of azithromycin; administer azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Potentiates anticoagulant effect; monitor PT/INR closely.
Nelfinavir
Increased azithromycin concentrations; monitor for known azithromycin side effects.
Cyclosporine
Increased cyclosporine levels; use with caution and monitor cyclosporine concentrations.
Ergot alkaloids
Potential for ergotism (vasospasm and dysesthesia) due to severe vasoconstriction; concomitant use is contraindicated.
Storage
Store powder below 30°C in a dry place, away from light. After reconstitution, store at room temperature (20-25°C) or refrigerated (2-8°C) as per specific product instructions, for the recommended duration.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures as clinically indicated. Gastric lavage and supportive therapy are recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Azithromycin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
May increase serum digoxin levels; monitor digoxin levels.
Antacids
Reduced peak plasma levels of azithromycin; administer azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Potentiates anticoagulant effect; monitor PT/INR closely.
Nelfinavir
Increased azithromycin concentrations; monitor for known azithromycin side effects.
Cyclosporine
Increased cyclosporine levels; use with caution and monitor cyclosporine concentrations.
Ergot alkaloids
Potential for ergotism (vasospasm and dysesthesia) due to severe vasoconstriction; concomitant use is contraindicated.
Storage
Store powder below 30°C in a dry place, away from light. After reconstitution, store at room temperature (20-25°C) or refrigerated (2-8°C) as per specific product instructions, for the recommended duration.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures as clinically indicated. Gastric lavage and supportive therapy are recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Azithromycin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
As per manufacturer's instructions on the packaging, usually 24-36 months. Reconstituted suspension typically 5-10 days.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of azithromycin for its approved indications globally.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment or during prolonged use)
- Renal function tests (in patients with severe renal impairment)
- ECG (for patients with known or suspected QT prolongation risk factors)
Doctor Notes
- Ensure patient compliance with the full course to prevent resistance.
- Advise parents/caregivers on proper measurement and administration of the suspension.
- Monitor for signs of C. difficile infection if prolonged diarrhea occurs after treatment.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Shake the suspension well before each use.
- Store reconstituted suspension as directed (usually at room temperature or refrigerated, depending on product).
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Azithromycin may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects.
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