Anaroxyl
Generic Name
Anaroxyl 25 mg Tablet
Manufacturer
Prime Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| anaroxyl 25 mg tablet | ৳ 19.75 | ৳ 197.50 |
Description
Overview of the medicine
Anaroxyl 25 mg Tablet is an antidepressant belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class. It is primarily used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder. It helps to improve mood and feelings of well-being.
Uses & Indications
Dosage
Adults
Initial dose 25 mg once daily, may be increased to 50-100 mg daily after several weeks based on response. Max 200 mg/day.
Elderly
Lower initial dose of 12.5 mg once daily, gradually increase to 25-50 mg daily. Max 100 mg/day.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe impairment; consider lower doses.
How to Take
Take orally, once daily, with or without food. It is recommended to take it at the same time each day to maintain consistent levels in the body.
Mechanism of Action
Anaroxyl selectively inhibits the reuptake of serotonin (5-HT) by the presynaptic neuron, thereby increasing the concentration of serotonin in the synaptic cleft. This leads to enhanced serotonergic neurotransmission in the central nervous system, which is believed to be responsible for its antidepressant and anxiolytic effects.
Pharmacokinetics
Onset
Initial therapeutic effects may be seen within 2-4 weeks, full effects may take 6-8 weeks.
Excretion
Excreted predominantly via urine (approximately 80%) and feces (approximately 20%) as metabolites.
Half life
Approximately 20-30 hours, allowing for once-daily dosing.
Absorption
Well absorbed from the gastrointestinal tract, peak plasma concentrations reached within 4-8 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP2D6 enzymes, to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Anaroxyl or any excipients
- •Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI
- •Concomitant use with Pimozide
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability).
NSAIDs
Increased risk of gastrointestinal bleeding.
Tramadol
Increased risk of serotonin syndrome.
Triptans
Increased risk of serotonin syndrome.
Warfarin
May enhance anticoagulant effect, monitor INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, tachycardia, tremor, agitation, and rarely, seizures or coma. Management involves supportive care, maintaining an open airway, monitoring cardiac and vital signs. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Anaroxyl should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in retail pharmacies and hospitals
Approval Status
Approved by regulatory bodies in various countries, including DGDA Bangladesh
Patent Status
Patent expired
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Global Brand Names
International brand names for this medicine
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