Anefer
Generic Name
Iron Sucrose
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| anefer 100 mg injection | ৳ 327.26 | N/A |
Description
Overview of the medicine
Anefer 100 mg Injection contains iron sucrose, a complex of ferric hydroxide and sucrose. It is used to treat iron deficiency anemia in patients undergoing hemodialysis who are receiving erythropoietin therapy, and in other patients with chronic kidney disease (CKD) who require intravenous iron.
Uses & Indications
Dosage
Adults
Typical total cumulative dose is 1000 mg of iron, administered in 10 individual doses of 100 mg infused over 15 minutes each. Can be given as a single 100 mg dose up to 3 times per week.
Elderly
No specific dosage adjustment required, but monitor for adverse reactions.
Renal_impairment
Used specifically for chronic kidney disease patients, follow standard adult dosing.
How to Take
Administer intravenously via slow injection or infusion after dilution. Do not administer undiluted. Should be given under medical supervision.
Mechanism of Action
Iron sucrose complex is dissociated by the reticuloendothelial system into iron and sucrose. The iron is then transported to the bone marrow where it is incorporated into hemoglobin, and to other tissues for storage (e.g., ferritin). This increases serum iron levels and supports erythropoiesis.
Pharmacokinetics
Onset
Hemoglobin increase typically observed within 2-4 weeks after initiating treatment.
Excretion
Primarily through reticuloendothelial system uptake; very little iron is excreted renally or fecally.
Half life
Terminal elimination half-life is approximately 6 hours.
Absorption
Administered intravenously, hence bioavailability is 100%. Iron sucrose is rapidly distributed from the plasma.
Metabolism
The sucrose component is eliminated, and the iron is transported to the bone marrow for hemoglobin synthesis or stored.
Side Effects
Contraindications
- Known hypersensitivity to iron sucrose or any of its components
- Anemia not caused by iron deficiency
- Iron overload or disturbances in iron utilization
Drug Interactions
ACE inhibitors
Potentiate the hypotensive effect of iron sucrose.
Oral Iron Preparations
Reduced absorption of oral iron; should not be given concomitantly.
Storage
Store below 30°C. Do not freeze. Protect from light.
Overdose
Overdose can lead to iron overload. Treatment involves supportive measures and potentially chelation therapy (e.g., deferoxamine) if severe.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Caution during lactation; iron sucrose may pass into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to iron sucrose or any of its components
- Anemia not caused by iron deficiency
- Iron overload or disturbances in iron utilization
Drug Interactions
ACE inhibitors
Potentiate the hypotensive effect of iron sucrose.
Oral Iron Preparations
Reduced absorption of oral iron; should not be given concomitantly.
Storage
Store below 30°C. Do not freeze. Protect from light.
Overdose
Overdose can lead to iron overload. Treatment involves supportive measures and potentially chelation therapy (e.g., deferoxamine) if severe.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Caution during lactation; iron sucrose may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check product label
Availability
Hospitals, clinics, pharmacies
Approval Status
Approved by regulatory authorities worldwide (e.g., FDA, EMA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of iron sucrose in treating iron deficiency anemia in various patient populations, particularly those with chronic kidney disease. Ongoing research may explore new indications or formulations.
Lab Monitoring
- Hemoglobin and hematocrit
- Serum ferritin
- Transferrin saturation (TSAT)
Doctor Notes
- Administer test dose cautiously for patients with a history of drug allergies.
- Monitor for signs of hypersensitivity during and after administration.
- Ensure resuscitation equipment is readily available.
Patient Guidelines
- Report any allergic reactions immediately
- Do not take oral iron supplements unless advised by your doctor
- Inform your doctor about all other medications you are taking
Missed Dose Advice
Consult your doctor or nurse. They will advise you on the next scheduled dose.
Driving Precautions
May cause dizziness or lightheadedness, especially after the first dose. Avoid driving or operating machinery if affected.
Lifestyle Advice
- Maintain a balanced diet rich in iron (though oral iron is not the primary route for treatment with Anefer)
- Stay hydrated
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