Anefer
Generic Name
Iron Sucrose
Manufacturer
Example Pharmaceutical Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| anefer 200 mg injection | ৳ 600.00 | N/A |
Description
Overview of the medicine
Anefer 200 mg Injection is an intravenous iron replacement product used to treat iron deficiency anemia in patients who cannot tolerate or respond to oral iron therapy, or in those with chronic kidney disease.
Uses & Indications
Dosage
Adults
Dosage is individualized based on total iron deficit. Common regimen: 200 mg elemental iron administered slowly over 30-60 minutes, 1-3 times per week, for several weeks. Max dose 200 mg per single administration; cumulative weekly dose up to 1000 mg.
Elderly
Similar to adult dosage; caution may be advised in patients with multiple comorbidities.
Renal_impairment
Primary indication for use, dosage as per adult recommendations or specific protocols for CKD patients.
How to Take
Anefer 200 mg Injection must be administered as an intravenous infusion, slowly over 30-60 minutes, usually diluted in saline. It should only be administered by healthcare professionals in a setting where resuscitation facilities are available.
Mechanism of Action
Iron sucrose replenishes body iron stores. The iron in iron sucrose is delivered to the cells of the reticuloendothelial system, primarily in the liver, spleen, and bone marrow, where it is released and incorporated into hemoglobin, myoglobin, and iron-containing enzymes.
Pharmacokinetics
Onset
Iron becomes available for erythropoiesis rapidly after administration.
Excretion
Small amounts of unmetabolized iron are excreted in urine. The iron is primarily utilized or stored.
Half life
Terminal half-life is approximately 6 to 12 hours for total iron.
Absorption
Bypasses gastrointestinal absorption; directly administered intravenously.
Metabolism
The sucrose component is metabolized. Iron is released and handled by the body's iron metabolism pathways.
Side Effects
Contraindications
- Hypersensitivity to iron sucrose or any of its components.
- Anemia not caused by iron deficiency.
- Evidence of iron overload (e.g., hemochromatosis) or disturbances in iron utilization.
Drug Interactions
ACE Inhibitors
May enhance the systemic effects of IV iron and increase the risk of adverse reactions, especially hypotension.
Oral Iron Preparations
Concurrent administration of oral iron may reduce the absorption of oral iron. Administer IV iron only when oral iron is insufficient or contraindicated.
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Overdose can lead to iron overload, which may manifest as hemochromatosis. Management involves supportive care and, in severe cases, chelation therapy with an iron chelator like deferoxamine.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Iron sucrose is excreted into human milk in small amounts; generally considered safe during lactation, but caution is advised.
Side Effects
Contraindications
- Hypersensitivity to iron sucrose or any of its components.
- Anemia not caused by iron deficiency.
- Evidence of iron overload (e.g., hemochromatosis) or disturbances in iron utilization.
Drug Interactions
ACE Inhibitors
May enhance the systemic effects of IV iron and increase the risk of adverse reactions, especially hypotension.
Oral Iron Preparations
Concurrent administration of oral iron may reduce the absorption of oral iron. Administer IV iron only when oral iron is insufficient or contraindicated.
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Overdose can lead to iron overload, which may manifest as hemochromatosis. Management involves supportive care and, in severe cases, chelation therapy with an iron chelator like deferoxamine.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Iron sucrose is excreted into human milk in small amounts; generally considered safe during lactation, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies globally
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of iron sucrose in treating iron deficiency anemia in various patient populations, particularly those with chronic kidney disease.
Lab Monitoring
- Hemoglobin and hematocrit levels (before and during treatment).
- Serum ferritin and transferrin saturation (before and during treatment).
- Total iron-binding capacity (TIBC).
Doctor Notes
- Always monitor patients for hypersensitivity reactions during and after administration.
- Administer slowly to minimize the risk of hypotension.
- Individualize the total cumulative dose based on patient's iron deficit.
Patient Guidelines
- This medication will be given by a healthcare professional.
- Report any unusual or severe side effects immediately.
- Ensure you attend all scheduled follow-up appointments and laboratory tests.
Missed Dose Advice
If a dose is missed, contact your doctor or healthcare provider to reschedule the administration. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness; patients should avoid driving or operating machinery if they experience dizziness or lightheadedness after administration.
Lifestyle Advice
- Maintain a balanced diet as advised by your doctor, though IV iron directly bypasses dietary intake.
- Follow all medical advice for managing underlying conditions, especially chronic kidney disease.
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