Antanil
Generic Name
Esomeprazole
Manufacturer
Various manufacturers globally
Country
Global
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Description
Overview of the medicine
Antanil (Esomeprazole) is a proton pump inhibitor used to treat conditions caused by excess stomach acid, such as GERD, peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily with appropriate antibiotics for 7-10 days.
Elderly
No specific dosage adjustment is usually required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dosage adjustment is needed for patients with renal impairment.
How to Take
Take Antanil capsules at least one hour before a meal. Swallow the capsule whole with water. Do not chew, crush, or open the capsule.
Mechanism of Action
Esomeprazole selectively inhibits the H+/K+-ATPase enzyme system (proton pump) located at the secretory surface of the gastric parietal cells, thereby blocking the final step of acid production.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly via urine (about 80%) and feces (about 20%) as inactive metabolites.
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations occur in about 1-2 hours. Bioavailability is approximately 89% after repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin.
Warfarin
Increased INR and prothrombin time.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase methotrexate plasma levels, potentially leading to toxicity.
Atazanavir/Nelfinavir
Reduced plasma concentrations of these antiretrovirals.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms are generally mild and include gastrointestinal disturbances and fatigue. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Exercise caution when administering to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Known hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin.
Warfarin
Increased INR and prothrombin time.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase methotrexate plasma levels, potentially leading to toxicity.
Atazanavir/Nelfinavir
Reduced plasma concentrations of these antiretrovirals.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms are generally mild and include gastrointestinal disturbances and fatigue. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Exercise caution when administering to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on specific formulation and manufacturer.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of various acid-related disorders, including GERD, erosive esophagitis, and H. pylori eradication.
Lab Monitoring
- Magnesium levels (for prolonged therapy)
- Liver function tests (in patients with severe hepatic impairment)
- Vitamin B12 levels (for long-term use)
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with treatment goals.
- Monitor magnesium levels periodically in patients on prolonged therapy or concomitant with digoxin or diuretics.
- Investigate any new or worsening symptoms, especially dysphagia, odynophagia, or unintentional weight loss, to rule out malignancy.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor.
- Inform your doctor about all medications, supplements, and herbal products you are taking.
- Report any unusual or severe side effects to your healthcare provider immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Esomeprazole may cause dizziness or visual disturbances in some patients. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy foods, caffeine, and alcohol to help reduce acid reflux symptoms.
- Maintain a healthy weight and avoid lying down immediately after meals.
- Elevate the head of your bed if you experience nighttime heartburn.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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