Apevit-B
Generic Name
Cyproheptadine Hydrochloride with B vitamins
Manufacturer
Generic Manufacturer (Various)
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| apevit b 5 mg syrup | ৳ 23.00 | N/A |
Description
Overview of the medicine
Apevit-B 5 mg syrup is a combination medication containing Cyproheptadine Hydrochloride and B vitamins. It is primarily used as an appetite stimulant and for the symptomatic relief of allergic conditions.
Uses & Indications
Dosage
Adults
Adults: 10 mL (5 mg cyproheptadine) 2-3 times daily, or as directed by physician.
Elderly
Elderly: Lower doses may be required due to increased sensitivity to anticholinergic effects. Consult a physician.
Renal_impairment
Renal impairment: Use with caution. Dosage adjustment may be necessary. Consult a physician.
How to Take
Administer orally. Can be taken with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Cyproheptadine acts as a potent H1-receptor antagonist and also possesses antiserotonergic activity, which is believed to contribute to its appetite-stimulating effects. It also has anticholinergic and mild sedative properties. B vitamins serve as coenzymes in various metabolic pathways essential for energy production and cell function.
Pharmacokinetics
Onset
Appetite stimulation typically within 30-60 minutes.
Excretion
Cyproheptadine and its metabolites are primarily excreted in the urine, with some fecal excretion. B vitamins are excreted predominantly in the urine.
Half life
Cyproheptadine: Approximately 8 hours. B vitamins: Vary, generally short.
Absorption
Cyproheptadine is well absorbed from the gastrointestinal tract. B vitamins are water-soluble and readily absorbed.
Metabolism
Cyproheptadine is extensively metabolized in the liver, primarily by conjugation. B vitamins are metabolized in various tissues.
Side Effects
Contraindications
- Hypersensitivity to Cyproheptadine or any component of the formulation
- Acute asthmatic attack
- Narrow-angle glaucoma
- Urinary retention (e.g., due to prostatic hypertrophy)
- Stenosing peptic ulcer
- Symptomatic prostatic hypertrophy
- Concomitant use with MAO inhibitors
- Newborn or premature infants
- Breastfeeding mothers
Drug Interactions
MAO Inhibitors
Concurrent use may prolong and intensify the anticholinergic effects of cyproheptadine.
Tricyclic Antidepressants
May enhance the anticholinergic effects.
CNS Depressants (e.g., alcohol, hypnotics, sedatives, tranquilizers)
May produce additive central nervous system depression.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, ataxia, dry mouth, fixed dilated pupils, flushing, gastrointestinal symptoms, and in children, excitation, hallucinations, and convulsions. Management involves symptomatic and supportive treatment. Induce emesis if not contraindicated, or perform gastric lavage.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. It is not known whether cyproheptadine is excreted in human milk; therefore, due to the potential for serious adverse reactions in nursing infants, breastfeeding is not recommended.
Side Effects
Contraindications
- Hypersensitivity to Cyproheptadine or any component of the formulation
- Acute asthmatic attack
- Narrow-angle glaucoma
- Urinary retention (e.g., due to prostatic hypertrophy)
- Stenosing peptic ulcer
- Symptomatic prostatic hypertrophy
- Concomitant use with MAO inhibitors
- Newborn or premature infants
- Breastfeeding mothers
Drug Interactions
MAO Inhibitors
Concurrent use may prolong and intensify the anticholinergic effects of cyproheptadine.
Tricyclic Antidepressants
May enhance the anticholinergic effects.
CNS Depressants (e.g., alcohol, hypnotics, sedatives, tranquilizers)
May produce additive central nervous system depression.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, ataxia, dry mouth, fixed dilated pupils, flushing, gastrointestinal symptoms, and in children, excitation, hallucinations, and convulsions. Management involves symptomatic and supportive treatment. Induce emesis if not contraindicated, or perform gastric lavage.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. It is not known whether cyproheptadine is excreted in human milk; therefore, due to the potential for serious adverse reactions in nursing infants, breastfeeding is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, check specific packaging for details.
Availability
Available in pharmacies nationwide
Approval Status
Approved by local regulatory bodies
Patent Status
Off-patent
Clinical Trials
Cyproheptadine has been extensively studied for its antihistaminic and appetite-stimulating properties. B vitamins have well-established roles in human nutrition. Clinical trials for this specific combination primarily focus on safety and efficacy in appetite stimulation and allergic conditions.
Lab Monitoring
- Routine laboratory monitoring is not generally required for healthy individuals. Periodic complete blood counts (CBC) and liver function tests (LFTs) may be considered during prolonged therapy, especially in susceptible patients.
Doctor Notes
- Before prescribing, evaluate the underlying cause of poor appetite.
- Advise patients about potential drowsiness and to avoid activities requiring alertness.
- Monitor for anticholinergic side effects, especially in elderly patients.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not drive or operate heavy machinery if you experience drowsiness.
- Avoid alcohol while taking this medicine.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause drowsiness, dizziness, or blurred vision. Avoid driving, operating machinery, or performing tasks requiring mental alertness until you know how this medication affects you.
Lifestyle Advice
- Maintain a balanced diet and regular exercise to support overall health.
- For appetite stimulation, small frequent meals may be more beneficial than large meals.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Apevit-B Brand
Other medicines available under the same brand name
