Apevit-B
Generic Name
Cyproheptadine Hydrochloride + Vitamin B Complex
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| apevit b 5 mg tablet | ৳ 0.40 | N/A |
Description
Overview of the medicine
Apevit-B 5 mg Tablet is a combination medicine containing Cyproheptadine and Vitamin B Complex. It is primarily used to stimulate appetite, promote weight gain, and treat various allergic conditions.
Uses & Indications
Dosage
Adults
1 tablet 2-3 times daily, or as directed by the physician. Dosage should be individualized and adjusted according to the patient's response.
Elderly
Lower initial doses may be required due to increased susceptibility to side effects. Use with caution.
Renal_impairment
Use with caution. Dose adjustment may be necessary in severe renal impairment.
How to Take
Administer orally with or without food. For appetite stimulation, it is often recommended to take it before meals.
Mechanism of Action
Cyproheptadine acts as a serotonin and histamine H1-receptor antagonist. Its serotonin antagonistic property is believed to stimulate appetite. As an H1-receptor antagonist, it helps in alleviating allergic symptoms. Vitamin B complex provides essential vitamins for metabolism and overall health.
Pharmacokinetics
Onset
Antihistaminic effects usually begin within 15-60 minutes. Appetite stimulation is more gradual.
Excretion
Mainly excreted in urine (as metabolites) and some in feces.
Half life
The elimination half-life of cyproheptadine is approximately 8-16 hours.
Absorption
Cyproheptadine is well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are reached in 6-9 hours.
Metabolism
Extensively metabolized in the liver, primarily via glucuronidation. B vitamins are metabolized in various tissues.
Side Effects
Contraindications
- Hypersensitivity to cyproheptadine or any component of the formulation.
- Acute asthma attack.
- Newborns or premature infants.
- Breastfeeding mothers.
- Angle-closure glaucoma.
- Stenosing peptic ulcer.
- Symptomatic prostatic hypertrophy.
- Bladder neck obstruction.
- Pyloroduodenal obstruction.
- Concomitant use with MAO inhibitors.
Drug Interactions
MAO Inhibitors (e.g., phenelzine, tranylcypromine)
May prolong and intensify the anticholinergic effects of cyproheptadine.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
Increased central nervous system (CNS) depression, drowsiness, and sedation.
Anticholinergic drugs (e.g., tricyclic antidepressants, atropine)
Potentiation of anticholinergic side effects like dry mouth, urinary retention, blurred vision.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, ataxia, hallucinations, convulsions, dry mouth, fixed dilated pupils, flushing, and gastrointestinal symptoms. In severe cases, coma, respiratory depression, and cardiovascular collapse may occur. Treatment is symptomatic and supportive. Gastric lavage or activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefits outweigh the risks. Contraindicated in breastfeeding mothers due to the potential for adverse effects on the infant.
Side Effects
Contraindications
- Hypersensitivity to cyproheptadine or any component of the formulation.
- Acute asthma attack.
- Newborns or premature infants.
- Breastfeeding mothers.
- Angle-closure glaucoma.
- Stenosing peptic ulcer.
- Symptomatic prostatic hypertrophy.
- Bladder neck obstruction.
- Pyloroduodenal obstruction.
- Concomitant use with MAO inhibitors.
Drug Interactions
MAO Inhibitors (e.g., phenelzine, tranylcypromine)
May prolong and intensify the anticholinergic effects of cyproheptadine.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
Increased central nervous system (CNS) depression, drowsiness, and sedation.
Anticholinergic drugs (e.g., tricyclic antidepressants, atropine)
Potentiation of anticholinergic side effects like dry mouth, urinary retention, blurred vision.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, ataxia, hallucinations, convulsions, dry mouth, fixed dilated pupils, flushing, and gastrointestinal symptoms. In severe cases, coma, respiratory depression, and cardiovascular collapse may occur. Treatment is symptomatic and supportive. Gastric lavage or activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefits outweigh the risks. Contraindicated in breastfeeding mothers due to the potential for adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Cyproheptadine has been extensively studied for its antihistaminic and appetite-stimulating effects through numerous clinical trials. The efficacy and safety of B vitamin supplementation are well-established.
Lab Monitoring
- No specific routine lab monitoring is required for short-term use.
- For long-term use, periodic monitoring of liver function tests may be considered (though hepatotoxicity is rare).
Doctor Notes
- Counsel patients on potential drowsiness and its impact on driving and operating machinery.
- Monitor weight and growth parameters, especially in pediatric and adolescent patients prescribed for appetite stimulation.
- Exercise caution in patients with underlying cardiac conditions due to anticholinergic effects.
Patient Guidelines
- Do not drive or operate heavy machinery until you know how this medicine affects you, as it may cause drowsiness.
- Avoid alcohol consumption while taking this medication.
- Inform your doctor about any pre-existing medical conditions, especially glaucoma, prostate enlargement, or asthma.
- Complete the full course of treatment as prescribed by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Apevit-B may cause drowsiness, dizziness, and impaired coordination. Patients should be warned not to engage in activities requiring mental alertness, such as driving a vehicle or operating hazardous machinery, until their response to the medication is known.
Lifestyle Advice
- Maintain a balanced and nutritious diet to support overall health and weight gain.
- Engage in moderate physical activity as advised by your healthcare provider.
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