Apidone
Generic Name
Aripiprazole
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| apidone 10 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Aripiprazole is an atypical antipsychotic medication used to treat mental health conditions such as schizophrenia, bipolar I disorder (manic or mixed episodes), and as an add-on treatment for major depressive disorder. It helps to restore the balance of certain natural substances (neurotransmitters) in the brain.
Uses & Indications
Dosage
Adults
For Schizophrenia: Initial 10-15 mg once daily, target dose 10-30 mg/day. For Bipolar I Disorder: Initial 15 mg once daily, target dose 15-30 mg/day. For MDD (adjunct): Initial 2-5 mg once daily, target dose 5-15 mg/day.
Elderly
No specific dose adjustment is generally required, but caution is advised. Start with lower doses and titrate slowly.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Aripiprazole is thought to work by partially agonising dopamine D2 and serotonin 5-HT1A receptors, and antagonising serotonin 5-HT2A receptors. This unique combination helps stabilize dopamine and serotonin systems, improving symptoms of psychosis and mood disorders.
Pharmacokinetics
Onset
Therapeutic effects may take several days to weeks to fully manifest.
Excretion
Excreted primarily via feces (55%) and urine (25%).
Half life
The mean terminal elimination half-life is approximately 75 hours for aripiprazole and 94 hours for its active metabolite, dehydro-aripiprazole.
Absorption
Well absorbed after oral administration, peak plasma concentrations typically occur within 3-5 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4 enzymes.
Side Effects
Contraindications
- •Known hypersensitivity to aripiprazole or any of its components.
Drug Interactions
CYP3A4 inducers (e.g., carbamazepine, rifampin)
May decrease aripiprazole plasma levels. Dose increase of aripiprazole may be necessary.
CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
May increase aripiprazole plasma levels. Dose reduction of aripiprazole may be necessary.
Other CNS depressants (e.g., alcohol, benzodiazepines)
Increased risk of sedation and CNS depression.
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
May increase aripiprazole plasma levels. Dose reduction of aripiprazole may be necessary.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, vomiting, tremor, tachycardia, agitation, aggression, hypotension, extrapyramidal symptoms, and seizures. Management is primarily supportive, including maintaining an adequate airway, oxygenation, and ventilation. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms. Aripiprazole is excreted in human breast milk; a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA (for Aripiprazole)
Patent Status
Patent expired, generic versions available
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Global Brand Names
International brand names for this medicine
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