Ardance-L
Generic Name
Levosulpiride
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ardance l 10 mg tablet | ৳ 35.00 | ৳ 350.00 |
Description
Overview of the medicine
Ardance-L 10 mg Tablet contains Levosulpiride, a prokinetic agent used to treat symptoms of functional dyspepsia such as bloating, early satiety, epigastric pain, nausea, and vomiting. It works by increasing gastrointestinal motility.
Uses & Indications
Dosage
Adults
Typically 10-20 mg two to three times daily before meals, or as directed by physician.
Elderly
Lower doses may be considered due to potential reduced renal function. Max 25 mg twice daily.
Renal_impairment
Dosage reduction is required. For moderate impairment, 50% of the usual dose. For severe impairment, not recommended or significantly reduced.
How to Take
Take the tablet orally, preferably 15-30 minutes before meals. Do not chew or crush the tablet.
Mechanism of Action
Levosulpiride acts as a selective dopamine D2 receptor antagonist, primarily in the peripheral nervous system (gastrointestinal tract). By blocking D2 receptors, it increases acetylcholine release, which enhances gastrointestinal motility and tone, leading to improved gastric emptying and reduced reflux.
Pharmacokinetics
Onset
Within 30-60 minutes for prokinetic effects.
Excretion
Mainly excreted via urine, a small amount in feces.
Half life
Approximately 6-8 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Primarily metabolized in the liver to various inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Levosulpiride or any component of the formulation
- •Epilepsy
- •Mania
- •Phaeochromocytoma
- •Prolactin-dependent tumors (e.g., breast cancer)
- •Gastrointestinal hemorrhage, mechanical obstruction, or perforation
- •Pregnancy and lactation (unless strictly necessary)
Drug Interactions
CNS depressants
Increased sedation
Anticholinergic drugs
May reduce the prokinetic effect of Levosulpiride
Dopaminergic agonists
Antagonism of effects (e.g., Levodopa)
Drugs prolonging QT interval
Increased risk of arrhythmias
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, extrapyramidal symptoms (e.g., tremor, rigidity), hypotension, and sedation. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Not recommended during pregnancy and lactation unless the potential benefits outweigh the risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved in many countries (e.g., India, Bangladesh, Italy), not FDA approved in USA.
Patent Status
Generic available, patent expired for Levosulpiride
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Global Brand Names
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