Aride
Generic Name
Aripiprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aride 50 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Aripiprazole is an atypical antipsychotic medication primarily used to treat schizophrenia, bipolar I disorder, and as an add-on treatment for depression. It helps to restore the balance of certain natural substances (neurotransmitters) in the brain. Aride 50 mg tablet is a higher strength formulation for specific patient needs or maintenance therapy.
Uses & Indications
Dosage
Adults
For Schizophrenia, typical target dose is 10-30 mg once daily. For Bipolar Mania, 15 mg once daily as monotherapy. For adjunctive MDD, 2-15 mg once daily. A 50 mg dose may be used in some resistant cases or specific regimens as determined by a physician, but is generally higher than initial recommended doses.
Elderly
Lower starting doses are recommended (e.g., 5-10 mg/day) with slow titration, monitoring for increased sensitivity to side effects.
Renal_impairment
No dosage adjustment is generally required.
How to Take
Take Aride 50 mg tablet orally once daily, with or without food. Swallow the tablet whole with water; do not crush, chew, or break it.
Mechanism of Action
Aripiprazole's mechanism of action is thought to be due to partial agonism at D2 and 5-HT1A receptors and antagonism at 5-HT2A receptors. This unique pharmacological profile contributes to its mood-stabilizing and antipsychotic effects with a lower propensity for certain side effects compared to traditional antipsychotics.
Pharmacokinetics
Onset
Therapeutic effects may take several days to weeks to fully manifest. Acute agitation may respond faster with injectables.
Excretion
Excreted via feces (55%) and urine (25%).
Half life
Aripiprazole has an elimination half-life of approximately 75 hours, and its active metabolite, dehydro-aripiprazole, has a half-life of about 94 hours.
Absorption
Well absorbed orally, peak plasma concentrations typically within 3-5 hours. Absolute bioavailability is 87%.
Metabolism
Primarily metabolized by the liver enzymes CYP2D6 and CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to aripiprazole or any component of the formulation
Drug Interactions
CNS Depressants (e.g., alcohol, benzodiazepines)
Concomitant use may potentiate CNS depressive effects.
CYP3A4 Inducers (e.g., carbamazepine, rifampin, phenytoin)
May decrease aripiprazole levels; dose increase of aripiprazole may be needed.
CYP2D6 Inhibitors (e.g., fluoxetine, paroxetine, quinidine)
May increase aripiprazole levels; dose reduction of aripiprazole may be needed.
CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, clarithromycin)
May increase aripiprazole levels; dose reduction of aripiprazole may be needed.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence, vomiting, tachycardia, and potentially extrapyramidal symptoms or seizures. Management should be supportive, including airway management, oxygenation, ventilation, and cardiovascular monitoring. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms. Aripiprazole is excreted in human milk; advise women not to breastfeed during treatment.
Side Effects
Contraindications
- Known hypersensitivity to aripiprazole or any component of the formulation
Drug Interactions
CNS Depressants (e.g., alcohol, benzodiazepines)
Concomitant use may potentiate CNS depressive effects.
CYP3A4 Inducers (e.g., carbamazepine, rifampin, phenytoin)
May decrease aripiprazole levels; dose increase of aripiprazole may be needed.
CYP2D6 Inhibitors (e.g., fluoxetine, paroxetine, quinidine)
May increase aripiprazole levels; dose reduction of aripiprazole may be needed.
CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, clarithromycin)
May increase aripiprazole levels; dose reduction of aripiprazole may be needed.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence, vomiting, tachycardia, and potentially extrapyramidal symptoms or seizures. Management should be supportive, including airway management, oxygenation, ventilation, and cardiovascular monitoring. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms. Aripiprazole is excreted in human milk; advise women not to breastfeed during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
FDA approved, available in Bangladesh
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Aripiprazole has undergone extensive clinical trials supporting its efficacy and safety for approved indications, including studies on its long-term use and use in specific populations.
Lab Monitoring
- Baseline and periodic monitoring of blood glucose and lipid profile (cholesterol, triglycerides)
- Weight monitoring
- Complete Blood Count (CBC) if signs of infection or decreased white blood cells appear
- ECG if cardiovascular risk factors are present or prior to concomitant use with QT-prolonging drugs
Doctor Notes
- Closely monitor patients for suicidal ideation and changes in behavior, especially at the initiation of therapy or during dose adjustments.
- Assess for metabolic parameters (glucose, lipids, weight) regularly.
- Educate patients and caregivers about the signs of NMS and tardive dyskinesia.
- Consider pharmacogenomic testing for CYP2D6 if unexplained adverse effects or lack of efficacy occur.
Patient Guidelines
- Take medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor, as this may lead to withdrawal symptoms or relapse.
- Report any unusual side effects, especially uncontrollable movements, fever, or changes in mood, immediately to your doctor.
- Avoid alcohol while taking this medication as it can increase side effects.
- Be aware of the risk of orthostatic hypotension and rise slowly from a sitting or lying position.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Aripiprazole may cause drowsiness, dizziness, or visual disturbances, especially at the beginning of treatment. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to manage potential weight gain.
- Ensure adequate hydration.
- Practice good sleep hygiene for better mental health.
- Avoid smoking and illicit drug use.
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