Arinet
Generic Name
Desloratadine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| arinet 50 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Arinet (Desloratadine) is a non-drowsy antihistamine used to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria. It provides effective relief from sneezing, runny nose, itchy nose or eyes, congestion, and skin itching and hives.
Uses & Indications
Dosage
Adults
5 mg orally once daily, with or without food.
Elderly
No dose adjustment generally required, but caution is advised in elderly patients with renal or hepatic impairment.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min), 5 mg every other day is recommended.
Hepatic_impairment
For patients with hepatic impairment, 5 mg every other day is recommended.
How to Take
Take Arinet orally with a glass of water, with or without food. Do not crush or chew the tablet; swallow it whole.
Mechanism of Action
Desloratadine is a potent, selective, peripheral H1-receptor antagonist. It blocks the action of histamine, a substance in the body that causes allergic symptoms. It also exhibits anti-inflammatory effects by inhibiting the release of pro-inflammatory mediators from mast cells and basophils.
Pharmacokinetics
Onset
Onset of action within 1 hour.
Excretion
Primarily excreted via urine (41%) and feces (47%) as metabolites.
Half life
Terminal elimination half-life is approximately 27 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, via hydroxylation followed by glucuronidation. CYP2D6 is involved in metabolism.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe renal impairment should use with caution and dose adjustment.
Drug Interactions
Cimetidine
Co-administration with cimetidine increased desloratadine plasma levels, but without clinically significant safety concerns.
Fluoxetine
Co-administration with fluoxetine increased desloratadine plasma levels, but without clinically significant safety concerns.
Erythromycin
Co-administration with erythromycin increased desloratadine plasma levels, but without clinically significant safety concerns.
Ketoconazole
Co-administration with ketoconazole increased desloratadine plasma levels, but without clinically significant safety concerns.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, seek immediate medical attention. Symptoms may include somnolence, increased heart rate, and headache. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe renal impairment should use with caution and dose adjustment.
Drug Interactions
Cimetidine
Co-administration with cimetidine increased desloratadine plasma levels, but without clinically significant safety concerns.
Fluoxetine
Co-administration with fluoxetine increased desloratadine plasma levels, but without clinically significant safety concerns.
Erythromycin
Co-administration with erythromycin increased desloratadine plasma levels, but without clinically significant safety concerns.
Ketoconazole
Co-administration with ketoconazole increased desloratadine plasma levels, but without clinically significant safety concerns.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, seek immediate medical attention. Symptoms may include somnolence, increased heart rate, and headache. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date. Check package for exact expiry date.
Availability
Available in pharmacies and hospitals in Bangladesh
Approval Status
Approved by DGDA (Directorate General of Drug Administration, Bangladesh)
Patent Status
Patent expired, generic available
Clinical Trials
Desloratadine has undergone extensive clinical trials demonstrating its efficacy and safety in treating allergic rhinitis and chronic idiopathic urticaria in adults and pediatric patients.
Lab Monitoring
- Generally, no routine laboratory monitoring is required for patients taking desloratadine.
Doctor Notes
- Advise patients that while generally non-drowsy, individual responses may vary, and caution should be exercised when driving or operating machinery.
- Consider dose adjustment in patients with severe renal or hepatic impairment.
- Inform patients about potential for rare but serious hypersensitivity reactions.
Patient Guidelines
- Take Arinet exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor or pharmacist about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Arinet is generally considered non-drowsy, but individual responses can vary. If you experience drowsiness or dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- If Arinet causes drowsiness, avoid driving or operating heavy machinery.
- Limit or avoid alcohol consumption as it may increase the risk of drowsiness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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