Aristocort Plus
Generic Name
Triamcinolone Acetonide + Nystatin
Manufacturer
Various (e.g., Square Pharmaceuticals Ltd. in Bangladesh)
Country
Bangladesh (for local brands)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aristocort plus 1 01 cream | ৳ 40.00 | N/A |
Description
Overview of the medicine
Aristocort Plus cream is a topical medication combining a corticosteroid (Triamcinolone Acetonide) and an antifungal agent (Nystatin) used to treat various inflammatory skin conditions complicated by fungal infections.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area two to three times daily. Rub in gently.
Elderly
No specific dosage adjustment needed; use with caution due to thinner skin.
Renal_impairment
No dosage adjustment necessary for topical application due to minimal systemic absorption.
How to Take
For external use only. Apply a thin layer to the affected area and rub in gently. Do not apply to eyes, mouth, or other mucous membranes. Wash hands thoroughly before and after application.
Mechanism of Action
Triamcinolone Acetonide is a synthetic corticosteroid that possesses anti-inflammatory, antipruritic, and vasoconstrictive properties. It acts by inducing phospholipase A2 inhibitory proteins, which control the biosynthesis of inflammatory mediators. Nystatin is a polyene antifungal antibiotic that binds to sterols in the fungal cell membrane, altering permeability and causing cell leakage.
Pharmacokinetics
Onset
Within hours to days for anti-inflammatory effects.
Excretion
Absorbed Triamcinolone and its metabolites are primarily excreted by the kidneys; Nystatin is excreted unchanged in feces after oral administration, negligible topical excretion.
Half life
Systemic half-life for absorbed Triamcinolone varies, typically a few hours to days; Nystatin has negligible systemic absorption.
Absorption
Minimal systemic absorption through intact skin; increased with inflammation, occlusion, or prolonged use. Nystatin is not significantly absorbed from skin or mucous membranes.
Metabolism
Absorbed Triamcinolone is primarily metabolized in the liver; Nystatin is not significantly metabolized when applied topically.
Side Effects
Contraindications
- •Hypersensitivity to Triamcinolone Acetonide, Nystatin, or any component of the formulation
- •Viral skin infections (e.g., herpes simplex, varicella)
- •Tuberculous skin lesions
- •Perioral dermatitis
- •Rosacea
- •Primary bacterial skin infections
Drug Interactions
Other Topical Antifungals
Avoid concurrent use of other topical antifungals unless directed by a physician, to prevent potential for additive irritation or reduced efficacy.
Other Topical Corticosteroids
Avoid concurrent use of other topical corticosteroids unless directed by a physician, as it may increase systemic absorption and side effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with topical application is unlikely to produce systemic effects. Chronic excessive use may lead to symptoms of hypercortisolism (Cushing's syndrome), adrenal suppression, or local skin atrophy. Nystatin overdose is not expected to be toxic due to minimal absorption.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Topical corticosteroids should not be used extensively, in large amounts, or for prolonged periods in pregnant or lactating women. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (specifics vary by manufacturer)
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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