Medicine Information

Aronem

Name: Aronem
Brand: Aronem
Rating: 4.5 (117 reviews)

Powder for solution for injection/infusion500 mgAntibiotics (Carbapenems)ATC: J01DH02

Generic Name

Meropenem

Manufacturer

Aristo Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aronem 500 mg injection	৳ 750.00	N/A

Description

Overview of the medicine

Aronem 500 mg Injection is a potent carbapenem antibiotic used to treat a wide range of severe bacterial infections, including complicated intra-abdominal infections, skin and soft tissue infections, and bacterial meningitis.

Uses & Indications

Complicated intra-abdominal infections

Complicated skin and skin structure infections

Bacterial meningitis

Pneumonia (including hospital-acquired and ventilator-associated pneumonia)

Complicated urinary tract infections

Febrile neutropenia (as empiric therapy)

Dosage

Adults

Typical adult dosage is 500 mg to 1 g IV every 8 hours, depending on the type and severity of infection.

Elderly

Dosage adjustment is often required based on renal function (creatinine clearance).

Renal_impairment

Dosage must be reduced and/or interval extended based on creatinine clearance (e.g., for CrCl 26-50 mL/min, 500 mg every 12 hours; for CrCl 10-25 mL/min, 250 mg every 12 hours).

How to Take

Administer by intravenous infusion over 15 to 30 minutes, or by intravenous bolus injection over 3 to 5 minutes for doses up to 1 g. The powder should be reconstituted with sterile water for injection.

Mechanism of Action

Meropenem is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This disrupts the bacterial cell wall, leading to cell lysis and death.

Pharmacokinetics

Onset

Rapid onset of action.

Excretion

Mainly excreted by the kidneys (approximately 70% as unchanged drug) within 12 hours.

Half life

Approximately 1 hour in adults with normal renal function.

Absorption

Rapid and complete absorption after intravenous administration.

Metabolism

Primarily metabolized by hydrolysis of the beta-lactam ring to an inactive metabolite. Hepatic metabolism is minimal.

Side Effects

Contraindications

Known hypersensitivity to meropenem or any other carbapenem antibiotics.
Known hypersensitivity to any other beta-lactam antibacterial agents (e.g., penicillins, cephalosporins).

Drug Interactions

Probenecid

Probenecid competes with meropenem for active tubular secretion, leading to increased plasma concentrations and prolonged half-life of meropenem.

Valproic acid

Co-administration with meropenem can decrease valproic acid levels, potentially leading to sub-therapeutic levels and increased risk of seizures. Monitoring of valproic acid levels is recommended.

Storage

Store dry powder vials below 25°C, protected from light. Reconstituted solution stability varies (e.g., 2 hours at room temperature, 18 hours at 2-8°C).

Overdose

In case of overdose, meropenem can be removed by hemodialysis. Symptomatic and supportive treatment should be initiated.

Pregnancy & Lactation

Pregnancy Category B. Meropenem should be used during pregnancy only if clearly needed. It is excreted in human milk in very low concentrations; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial per pack

Shelf Life

Typically 2-3 years, refer to product labeling for exact expiry.

Availability

Pharmacies and Hospitals

Approval Status

Approved by DGDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have demonstrated meropenem's efficacy and safety in treating a broad range of bacterial infections in various patient populations, including pediatric and critically ill patients.

Lab Monitoring

Renal function tests (creatinine, BUN) for dose adjustment and monitoring.
Liver function tests (ALT, AST) if prolonged treatment.
Complete blood count (CBC) if prolonged treatment.

Doctor Notes

Adjust dosage carefully in patients with renal impairment.
Be prepared for potential hypersensitivity reactions, especially in patients with a history of allergy to beta-lactams.
Monitor for decreased valproic acid levels if co-administered.

Patient Guidelines

Inform your doctor immediately if you experience any signs of an allergic reaction (e.g., rash, itching, swelling, difficulty breathing).
Complete the full course of treatment as prescribed by your doctor, even if you start to feel better.
Do not stop the injection without consulting your doctor.

Missed Dose Advice

If a dose is missed, administer it as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.