Athexim
Generic Name
Levothyroxine Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| athexim 500 mg tablet | ৳ 45.00 | ৳ 315.00 |
Description
Overview of the medicine
Athexim is a synthetic thyroid hormone used to treat hypothyroidism.
Uses & Indications
Dosage
Adults
Initially 25-50 mcg daily, adjusted by 12.5-25 mcg every 2-4 weeks based on TSH levels.
Elderly
Start with a lower dose (e.g., 12.5-25 mcg daily) due to increased sensitivity.
Renal_impairment
No specific dosage adjustment is usually required, but monitor TSH levels closely.
How to Take
Take on an empty stomach, preferably 30-60 minutes before breakfast.
Mechanism of Action
Levothyroxine is converted to T3, which binds to thyroid hormone receptors and regulates gene expression.
Pharmacokinetics
Onset
Gradual, several days to weeks.
Excretion
Primarily in the urine, as metabolites.
Half life
6-7 days in euthyroid patients, 9-10 days in hypothyroid patients, and 3 days in hyperthyroid patients.
Absorption
Variable, depends on gastric pH. Absorption is approximately 70-80%.
Metabolism
Deiodination in the liver and peripheral tissues.
Side Effects
Contraindications
- Untreated hyperthyroidism
- Acute myocardial infarction
Drug Interactions
Warfarin
Levothyroxine can enhance the anticoagulant effects of warfarin, increasing the risk of bleeding.
Calcium Carbonate
Calcium carbonate can decrease levothyroxine absorption.
Storage
Store below 25°C, protect from light and moisture.
Overdose
Symptoms of overdose include palpitations, sweating, tremor, and nervousness. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Levothyroxine is generally safe during pregnancy but dose adjustments may be necessary. It is also safe during lactation.
Side Effects
Contraindications
- Untreated hyperthyroidism
- Acute myocardial infarction
Drug Interactions
Warfarin
Levothyroxine can enhance the anticoagulant effects of warfarin, increasing the risk of bleeding.
Calcium Carbonate
Calcium carbonate can decrease levothyroxine absorption.
Storage
Store below 25°C, protect from light and moisture.
Overdose
Symptoms of overdose include palpitations, sweating, tremor, and nervousness. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Levothyroxine is generally safe during pregnancy but dose adjustments may be necessary. It is also safe during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years
Availability
Pharmacies and Hospitals
Approval Status
FDA Approved, DGDA Approved
Patent Status
Off-Patent
WHO Essential Medicine
YesClinical Trials
Various clinical trials have established the efficacy and safety of levothyroxine in treating hypothyroidism.
Lab Monitoring
- TSH
- Free T4
Doctor Notes
- Regular monitoring of TSH levels is crucial.
- Adjust dosage based on clinical response and lab values.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medication without consulting your doctor.
- Report any signs of hyperthyroidism to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is close to the time for your next dose. Do not double the dose.
Driving Precautions
No specific precautions are usually necessary, but be aware of potential side effects.
Lifestyle Advice
- Maintain a consistent diet.
- Avoid taking the medication with certain supplements or medications.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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