Attentin
Generic Name
Dexamfetamine sulfate
Manufacturer
Takeda Pharmaceuticals
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| attentin 10 mg capsule | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Attentin 10 mg capsule contains Dexamfetamine sulfate, a central nervous system (CNS) stimulant primarily used to treat Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy. It helps increase attention and decrease hyperactivity and impulsiveness.
Uses & Indications
Dosage
Adults
For ADHD, typically 5-40 mg daily in divided doses. Initial dose usually 5 mg once or twice daily. For narcolepsy, 5-60 mg daily in divided doses.
Elderly
Lower initial doses are recommended, with careful titration due to increased sensitivity and potential comorbidities. Use with caution.
Renal_impairment
Dose adjustment is required; use with caution. Monitoring for adverse effects is important as excretion may be impaired.
How to Take
Take orally, with or without food. Avoid taking late in the day to prevent insomnia.
Mechanism of Action
Dexamfetamine works by increasing the levels of certain neurotransmitters, primarily dopamine and norepinephrine, in the brain. This action improves attention, focus, and reduces impulsive behavior and hyperactivity in individuals with ADHD.
Pharmacokinetics
Onset
Typically 30-60 minutes.
Excretion
Excreted renally, with the rate and extent dependent on urine pH (more acidic urine increases excretion).
Half life
Approximately 10-12 hours in adults, varying with urine pH.
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Primarily metabolized in the liver by the CYP2D6 enzyme, producing inactive metabolites.
Side Effects
Contraindications
- •Advanced arteriosclerosis
- •Symptomatic cardiovascular disease
- •Moderate to severe hypertension
- •Hyperthyroidism
- •Glaucoma
- •Agitated states
- •History of drug abuse
- •During or within 14 days of MAOI administration
Drug Interactions
MAOIs
Risk of hypertensive crisis.
Antacids/PPIs
May increase absorption and effects of dexamfetamine.
Tricyclic Antidepressants (TCAs)
May potentiate cardiovascular effects.
Acidifying agents (e.g., ascorbic acid)
Decrease urinary excretion and shorten half-life.
Alkalinizing agents (e.g., sodium bicarbonate)
Increase urinary excretion and prolong half-life.
Storage
Store at controlled room temperature (20°C to 25°C), away from moisture and heat. Keep out of reach of children.
Overdose
Symptoms of overdose include restlessness, tremor, hyperreflexia, rapid respiration, confusion, panic states, hallucinations, seizures, coma, arrhythmias, and hypertension or hypotension. Management is primarily symptomatic and supportive, including gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 2-3 years from the date of manufacture, specific to packaging.
Availability
Pharmacies worldwide
Approval Status
FDA Approved (Dextroamphetamine)
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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